SH2B2 and PLEKHA3

Data Source:
BioGRID (two hybrid)

		SH2B2	PLEKHA3
Description		SH2B adaptor protein 2	pleckstrin homology domain containing A3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Golgi Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding	Protein Binding Identical Protein Binding Phosphatidylinositol-4-phosphate Binding Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity
	Biological Process	Blood Coagulation Insulin Receptor Signaling Pathway Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway	Phosphatidylinositol Biosynthetic Process Biological_process Ceramide Transport Intermembrane Lipid Transfer Ceramide 1-phosphate Transport
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Type 2 diabetes ( 31049640)	Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)
Interacting Genes		42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13 EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417	8 interacting genes: DOK3 ERRFI1 MORF4L1 MRPL45 MYO15B RNMT SH2B2 TCL1B
Entrez ID		10603	65977
HPRD ID		16097	09688
Ensembl ID		ENSG00000160999	ENSG00000116095
Uniprot IDs		O14492	Q9HB20
PDB IDs		1Q2H	2KCJ 2MDX 3RCP
Enriched GO Terms of Interacting Partners?
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