SH2B2 and IL36RN

Data Source:
BioGRID (two hybrid)

		SH2B2	IL36RN
Description		SH2B adaptor protein 2	interleukin 36 receptor antagonist
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding
	Biological Process	Blood Coagulation Insulin Receptor Signaling Pathway Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway	Negative Regulation Of Cytokine-mediated Signaling Pathway Inflammatory Response To Antigenic Stimulus Inflammatory Response Cytokine-mediated Signaling Pathway Antifungal Humoral Response Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Innate Immune Response Cellular Response To Lipopolysaccharide
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	Interleukin-36 pathway
Drugs
Diseases
GWAS		Type 2 diabetes ( 31049640)	Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Stroke ( 26089329)
Interacting Genes		42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13 EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417	18 interacting genes: AGR2 AP3M1 CNOT4 CRACR2B DDIT4L HPCA INCA1 IRAK4 MCM6 REL SH2B2 SKIL SSBP2 SSBP3 SSBP4 UBL4B ZKSCAN4 ZNF512B
Entrez ID		10603	26525
HPRD ID		16097	16112
Ensembl ID		ENSG00000160999	ENSG00000136695
Uniprot IDs		O14492	A0A024R518 Q9UBH0
PDB IDs		1Q2H	4P0J 4P0K 4P0L
Enriched GO Terms of Interacting Partners?
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