SLC22A4 and PDZK1

Data Source:
HPRD (two hybrid, in vitro)

		SLC22A4	PDZK1
Description		solute carrier family 22 member 4	PDZ domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane	Plasma Membrane Brush Border Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Secondary Active Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Cation:cation Antiporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding	Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding
	Biological Process	Triglyceride Metabolic Process Sodium Ion Transport Body Fluid Secretion Carnitine Metabolic Process Organic Cation Transport Quaternary Ammonium Group Transport Carnitine Transport Xenobiotic Transport Amino Acid Import Across Plasma Membrane Carnitine Transmembrane Transport	Carnitine Transport Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Organic cation transport
Drugs		Levocarnitine
Diseases		Crohn's disease
GWAS		Acylcarnitine levels ( 26068415) Asthma ( 31619474) Asthma (sex interaction) ( 24824216) Asthma or allergic disease (pleiotropy) ( 29785011) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388 21102463) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 20031577) Fibrinogen levels ( 26561523) Granulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Intracranial aneurysm ( 33199917) Itch intensity from mosquito bite ( 28199695) Lymphocyte counts ( 32888494) Mean platelet volume ( 27863252) Metabolic traits ( 21886157) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Nasal polyps ( 30643255) Neutrophil count ( 27863252) Platelet count ( 32888494) Serum metabolite levels ( 23093944) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252)	Contrast sensitivity ( 24152035) Gout ( 32238385) Serum uric acid levels ( 30993211) Urate levels ( 31985003 20884846 31578528 23263486) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)
Interacting Genes		4 interacting genes: PDZD3 PDZK1 SLC9A3R1 SLC9A3R2	31 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I
Entrez ID		6583	5174
HPRD ID		09171	04829
Ensembl ID		ENSG00000197208	ENSG00000174827
Uniprot IDs		Q9H015	Q5T2W1
PDB IDs			2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?
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