PDZK1 and SLC22A12

Data Source:
HPRD (in vitro, two hybrid)

		PDZK1	SLC22A12
Description		PDZ domain containing 1	solute carrier family 22 member 12
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding	Urate Transmembrane Transporter Activity PDZ Domain Binding
	Biological Process	Carnitine Transport Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Organic Anion Transport Urate Transport Cellular Homeostasis Response To Drug Urate Metabolic Process Transmembrane Transport
Pathways			Organic anion transport Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)
Drugs			Sulfinpyrazone Lesinurad
Diseases			Renal hypouricemia (RHUC)
GWAS		Contrast sensitivity ( 24152035) Gout ( 32238385) Serum uric acid levels ( 30993211) Urate levels ( 31985003 20884846 31578528 23263486) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)	Gout ( 27899376) Gout (combined type) ( 32238385) Hyperuricemia ( 29124443) Renal function-related traits (urea) ( 22797727) Renal overload gout ( 27899376) Renal underexcretion gout ( 27899376) Serum uric acid levels ( 30993211 29124443 32514006 26902266) Systemic lupus erythematosus ( 26606652) Urate levels ( 21768215 31985003 31578528 20139978 23263486) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)
Interacting Genes		31 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	1 interacting genes: PDZK1
Entrez ID		5174	116085
HPRD ID		04829	06160
Ensembl ID		ENSG00000174827	ENSG00000197891
Uniprot IDs		Q5T2W1	B3KP53 Q96S37
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?
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