SLC1A5 and PLP1

Data Source:
BioGRID (two hybrid)

		SLC1A5	PLP1
Description		solute carrier family 1 member 5	proteolipid protein 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane Integral Component Of Membrane Melanosome Extracellular Exosome	Plasma Membrane Integrin Alphav-beta3 Complex Myelin Sheath Synapse
	Molecular Function	Virus Receptor Activity Protein Binding Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity Symporter Activity Signaling Receptor Activity Metal Ion Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Amino Acid Transport Glutamine Transport Glutamine Secretion Neutral Amino Acid Transport L-serine Transport Viral Entry Into Host Cell Protein Homotrimerization L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier L-glutamine Import Across Plasma Membrane	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Positive Regulation Of Cell Migration Neuron Projection Development Long-chain Fatty Acid Biosynthetic Process Axon Development AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transport
Pathways		Amino acid transport across the plasma membrane
Drugs		Asparagine Fluciclovine (18F)
Diseases			Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS		Conjunctival UV autofluorescence (CUVAF) ( 25590795) Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: APOL3 ERVW-1 PLP1 TBC1D17 TRARG1	86 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYBC1 DCT DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FNDC9 GAST GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1
Entrez ID		6510	5354
HPRD ID		00173	02321
Ensembl ID		ENSG00000105281	ENSG00000123560
Uniprot IDs		Q15758 Q59ES3	A0A0S2Z4D4 A8K9L3 B4DI30 P60201
PDB IDs		5LLM 5LLU 5LM4 5MJU 6GCT 6MP6 6MPB 6RVX 6RVY	2XPG
Enriched GO Terms of Interacting Partners?
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