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SKIL and PIAS4
Data Source:
HPRD
(two hybrid)
SKIL
PIAS4
Description
SKI like proto-oncogene
protein inhibitor of activated STAT 4
Image
No pdb structure
GO Annotations
Cellular Component
Acrosomal Vesicle
Nucleus
Nucleoplasm
Transcription Regulator Complex
Protein-containing Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
PML Body
Transferase Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Chromatin Binding
Protein Binding
SMAD Binding
RNA Polymerase II Transcription Factor Binding
DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
SUMO Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Blastocyst Formation
Lymphocyte Homeostasis
Cell Cycle Arrest
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Response To Cytokine
Negative Regulation Of Cell Differentiation
Positive Regulation Of Axonogenesis
Lens Fiber Cell Differentiation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Wnt Signaling Pathway
Protein Sumoylation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Sumoylation
Vitamin D Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Keratinocyte Apoptotic Process
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Vitamin D (calciferol) metabolism
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Estimated glomerular filtration rate (
31152163
)
Glomerular filtration rate (creatinine) (
26831199
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Prostate cancer (
21743467
)
Chronic lymphocytic leukemia (
28165464
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Interacting Genes
96 interacting genes:
ASCC3
CAMSAP1
CBX4
CDC16
CDC27
CHD3
CHPF
COL4A2
CPNE1
CPNE2
CPNE4
CXXC5
DEUP1
DHX30
DRG1
EEF1G
EIF4G2
ESR1
FAF1
FBLN1
FN1
FZR1
GAS8
GLUL
GOLGB1
HEY1
HEYL
HIPK1
HIPK3
HNRNPLL
IL36RN
KRT81
LRP1
MACF1
MORC4
MVP
MYG1
NCOR1
NCOR2
NEFL
NID1
NID2
NXF3
OIP5
PAPPA
PIAS1
PIAS3
PIAS4
PLCD3
PPL
PSG3
PSMC2
PTPRF
PYCR2
RNF4
RPS27
SASH1
SETDB1
SKI
SMAD1
SMAD2
SMAD3
SMAD4
SMUG1
SMURF2
SNRNP70
SNX17
SPARCL1
SRP72
STK16
SVEP1
TDG
TDP2
TFPI2
THAP5
THSD7A
TLE5
TPM2
TRAK1
TRIM62
TRIM69
TSKU
TTF2
UBE2I
UIMC1
USP25
VPS28
XPA
XRCC6
ZBTB3
ZBTB6
ZMYM2
ZMYM5
ZNF106
ZNF200
ZZEF1
85 interacting genes:
ACTN1
ALDOA
AR
AREL1
BARD1
BRCA1
BTAF1
CALCOCO2
CEBPD
CHD3
CLK1
COIL
ESRRA
FTH1
GADD45G
HDAC1
HDAC2
HNF4A
HNRNPUL1
HTT
IL15RA
IMMT
IMPDH2
IRF3
IRF7
KNTC1
KPNB1
KRT18
LAMP2
LCE1D
LEF1
LRIF1
MAGEH1
MAP1LC3A
MDC1
MPRIP
NEFL
NR4A2
OAZ1
OPTN
PARP1
PDE4A
PDE4D
PDE4DIP
PHF11
PHGDH
PIAS1
PIAS2
PLAG1
PRKCZ
PRPF40A
PTN
RIF1
SATB1
SERBP1
SERPINA5
SETDB1
SH3GL3
SKIL
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
SNAI2
SNIP1
SUMO1
SUMO2
SUMO3
TADA3
TCERG1
TICAM1
TOP2A
TP53
TRIM27
TRIM32
TRIM38
UBE2I
UBE2K
VHL
VIM
ZBTB34
ZHX1
ZNF512B
ZW10
Entrez ID
6498
51588
HPRD ID
01319
06910
Ensembl ID
ENSG00000136603
ENSG00000105229
Uniprot IDs
P12757
B3KMR4
Q8N2W9
PDB IDs
3EQ5
5C4V
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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