SKIL and KRT81

Data Source:
HPRD (two hybrid)

		SKIL	KRT81
Description		SKI like proto-oncogene	keratin 81
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex	Extracellular Space Cytosol Keratin Filament
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding SMAD Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Lymphocyte Homeostasis Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Response To Cytokine Negative Regulation Of Cell Differentiation Positive Regulation Of Axonogenesis Lens Fiber Cell Differentiation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Keratinization Cornification
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity	Keratinization Formation of the cornified envelope
Drugs
Diseases			Monilethrix
GWAS		Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Prostate cancer ( 21743467)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		96 interacting genes: ASCC3 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DEUP1 DHX30 DRG1 EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GAS8 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 HNRNPLL IL36RN KRT81 LRP1 MACF1 MORC4 MVP MYG1 NCOR1 NCOR2 NEFL NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMUG1 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TLE5 TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XPA XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1	23 interacting genes: CYSRT1 HOXA1 KRT14 KRT15 KRT16 KRT18 KRT19 KRT26 KRT27 KRT28 KRT31 KRT34 KRT35 KRT37 KRT38 KRT39 KRT40 KXD1 LCA5L MEOX2 OIP5 OTX1 SKIL
Entrez ID		6498	3887
HPRD ID		01319	03691
Ensembl ID		ENSG00000136603	ENSG00000205426
Uniprot IDs		P12757	Q14533
PDB IDs		3EQ5 5C4V
Enriched GO Terms of Interacting Partners?
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