GADD45A and NUCB2

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		GADD45A	NUCB2
Description		growth arrest and DNA damage inducible alpha	nucleobindin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Extracellular Space Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein N-terminus Binding Promoter-specific Chromatin Binding	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPKKK Activity DNA Repair Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Centrosome Cycle Negative Regulation Of Angiogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Mitotic Cell Cycle Arrest Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process	Small GTPase Mediated Signal Transduction Negative Regulation Of Appetite Regulation Of Catalytic Activity
Pathways		TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest FOXO-mediated transcription of cell cycle genes
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Mean corpuscular volume ( 29403010) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Optic disc size ( 31809533) Platelet distribution width ( 32888494) Red blood cell count ( 32888494)	Blood protein levels ( 29875488) Body mass index ( 26426971) Height ( 20881960) Mean platelet volume ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28739976) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		69 interacting genes: ADAP1 ASCC2 AURKA BAG6 CBY2 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B CNOT9 DCTN2 DNAJC13 EEF1A1 EEF1G ERG28 FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 H1-1 H2AC16 H2BC21 H3-4 H4-16 IGHM IGSF21 JMJD1C KHSRP LMO4 LNX2 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PARVG PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS1 RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135	12 interacting genes: ARL13B ASPH FFAR2 GADD45A GNAI3 GNAS NDN NR1I2 SLC7A1 SMARCD1 STAR XPO1
Entrez ID		1647	4925
HPRD ID		00528	09726
Ensembl ID		ENSG00000116717	ENSG00000070081
Uniprot IDs		A5JUZ3 P24522	P80303 Q2L696
PDB IDs		2KG4
Enriched GO Terms of Interacting Partners?
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