SMURF2 and UBE2D2

Data Source:
BioGRID (pull down, enzymatic study)

		SMURF2	UBE2D2
Description		SMAD specific E3 ubiquitin protein ligase 2	ubiquitin conjugating enzyme E2 D2
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Membrane Raft	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Protein Polyubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Peroxisome Protein Ubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein Autoubiquitination Protein K48-linked Ubiquitination
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Antigen processing: Ubiquitination & Proteasome degradation
Drugs			(R,R)-2,3-Butanediol
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Periodontitis (Mean PAL) ( 24024966)	Alzheimer's disease (late onset) ( 30820047) Body mass index ( 26426971) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Leukocyte telomere length ( 32109421)
Interacting Genes		91 interacting genes: ABRAXAS2 ACBD3 ACOX3 AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FKBP4 FLNB FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RNF20 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44	252 interacting genes: AMFR ANAPC11 ANAPC2 AREL1 ARIH2 ARRDC3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRAP BRCA1 BTRC CADPS2 CBL CBLB CBLC CCNB1 CDKN1B CHFR CNOT4 COP1 CUEDC1 CUL3 CYLD DCAF1 DDX58 DLST DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL17 FBXL3 FBXO2 FBXO4 FBXO7 FBXW2 FOXO1 G0S2 H3C1 H4C1 HACE1 HECTD1 HECTD3 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC4 HERC5 HUWE1 ILF3 ITCH KAT2B KCMF1 LNX1 LNX2 LRSAM1 LTN1 MAEA MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF6 MARCHF7 MDM2 MDM4 MEX3A MEX3C MGRN1 MIB1 MIB2 MID1 MID2 MKRN3 MUL1 MYCBP2 MYLIP NAT10 NBR1 NEDD4 NEDD4L NFKBIA NPR1 NSMCE1 OTUB1 PDZRN3 PELI1 PER2 PHF7 PHRF1 PJA1 PJA2 POLL POLM PRKN QSOX1 RAD18 RAF1 RAG1 RBCK1 RBX1 RC3H1 RC3H2 RCHY1 RELA RFFL RFWD3 RING1 RLIM RMND5A RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF125 RNF126 RNF13 RNF130 RNF135 RNF138 RNF14 RNF146 RNF150 RNF151 RNF166 RNF167 RNF168 RNF170 RNF181 RNF185 RNF186 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF224 RNF25 RNF26 RNF31 RNF34 RNF38 RNF4 RNF40 RNF43 RNF5 RNF7 RNF8 RSPRY1 RTF2 SIAH1 SIAH2 SMURF1 SMURF2 SNCA SOCS6 SPOP SQSTM1 STAM2 STK11 STUB1 SYVN1 TOPORS TRAF2 TRAF6 TRAF7 TRAIP TRIM10 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM35 TRIM36 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM46 TRIM47 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM65 TRIM7 TRIM8 TRIP12 TTC3 UBA1 UBA3 UBA5 UBA6 UBASH3B UBB UBC UBD UBE3A UBE3C UBE4A UBE4B UBOX5 UBR1 UBR2 UBR3 UBR4 UBR5 UBTD1 UFM1 UHRF2 UVSSA VHL VPS11 VPS18 WRN WSB1 WWP1 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		64750	7322
HPRD ID		06901	04268
Ensembl ID		ENSG00000108854	ENSG00000131508
Uniprot IDs		Q96DE7 Q9HAU4	P62837
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4	1UR6 1W4U 2CLW 2ESK 2ESO 2ESP 2ESQ 3A33 3JVZ 3JW0 3L1Y 3TGD 3ZNI 4A49 4A4B 4A4C 4AUQ 4DDG 4DDI 4LDT 4V3K 4V3L 4WZ3 5D0K 5D0M 5D1K 5D1L 5D1M 5EDV 5MNJ 5ULF 5ULH 5ULK 5VZW 5ZBU 6HPR 6SQO 6SQR 6SQS 6TTU 6W7Z 6W9D
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?