SMURF2 and TOP2A

Data Source:
BioGRID (enzymatic study)

		SMURF2	TOP2A
Description		SMAD specific E3 ubiquitin protein ligase 2	DNA topoisomerase II alpha
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Membrane Raft	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Centriole DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity	Magnesium Ion Binding DNA Binding Chromatin Binding RNA Binding DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity DNA Binding, Bending Enzyme Binding Protein Homodimerization Activity Histone Deacetylase Binding Ubiquitin Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Topological Change DNA Ligation Cellular Response To DNA Damage Stimulus Chromosome Segregation Female Meiotic Nuclear Division Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of DNA Duplex Unwinding
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins
Drugs			Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Dactinomycin Lomefloxacin Doxorubicin Norfloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone Banoxantrone SP1049C Amonafide Elsamitrucin 13-deoxydoxorubicin RTA 744 Aldoxorubicin ZEN-012 Amrubicin Becatecarin Annamycin Declopramide Finafloxacin
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Periodontitis (Mean PAL) ( 24024966)	Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		91 interacting genes: ABRAXAS2 ACBD3 ACOX3 AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FKBP4 FLNB FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RNF20 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44	29 interacting genes: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 FBXO28 HDAC1 HDAC2 JUN MAPK1 PIAS4 PIN1 PLK1 PRKCA PRKCB PRKCG RB1 RNF168 SMURF2 SRPK1 SUMO1 SUMO2 SUMO4 TOP2B TP53 UBE2I XPO1 YWHAE
Entrez ID		64750	7153
HPRD ID		06901	00536
Ensembl ID		ENSG00000108854	ENSG00000131747
Uniprot IDs		Q96DE7 Q9HAU4	P11388
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4	1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE
Enriched GO Terms of Interacting Partners?
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