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UBE2D2 and MDM2
Data Source:
BioGRID
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UBE2D2
MDM2
Description
ubiquitin conjugating enzyme E2 D2
MDM2 proto-oncogene
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytosol
Protein-containing Complex
Extracellular Exosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Body
Endocytic Vesicle Membrane
Protein-containing Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
Ubiquitin-protein Transferase Activity
Protein Binding
5S RRNA Binding
Zinc Ion Binding
Ligase Activity
SUMO Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ribonucleoprotein Complex Binding
Ubiquitin Binding
Protein N-terminus Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Disordered Domain Specific Binding
Biological Process
Protein Polyubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Peroxisome
Protein Ubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Positive Regulation Of Cell Population Proliferation
Viral Process
Protein Ubiquitination
Protein Deubiquitination
Protein Sumoylation
Protein Phosphopantetheinylation
Protein Destabilization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Transcription Factor Catabolic Process
Regulation Of Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Establishment Of Protein Localization
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Response To Antibiotic
Proteolysis Involved In Cellular Protein Catabolic Process
Protein Autoubiquitination
Protein-containing Complex Assembly
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Hypoxia
Cellular Response To Gamma Radiation
Cellular Response To Actinomycin D
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Amyloid Fibril Formation
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation
AKT phosphorylates targets in the cytosol
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
Trafficking of AMPA receptors
Constitutive Signaling by AKT1 E17K in Cancer
Ub-specific processing proteases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Stabilization of p53
Regulation of RUNX3 expression and activity
Drugs
(R,R)-2,3-Butanediol
Zinc
Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Choriocarcinoma
Osteosarcoma
Glioma
Penile cancer
Alveolar rhabdomyosarcoma
GWAS
Alzheimer's disease (late onset) (
30820047
)
Body mass index (
26426971
)
Immune reponse to smallpox (secreted IFN-alpha) (
22610502
)
Leukocyte telomere length (
32109421
)
Pneumoconiosis in silica exposure (
24986923
)
Red blood cell count (
32888494
)
Interacting Genes
252 interacting genes:
AMFR
ANAPC11
ANAPC2
AREL1
ARIH2
ARRDC3
BARD1
BFAR
BIRC2
BIRC3
BIRC7
BIRC8
BMI1
BRAP
BRCA1
BTRC
CADPS2
CBL
CBLB
CBLC
CCNB1
CDKN1B
CHFR
CNOT4
COP1
CUEDC1
CUL3
CYLD
DCAF1
DDX58
DLST
DTX1
DTX2
DTX3
DTX3L
DZIP3
EPS15
F12
FBXL17
FBXL3
FBXO2
FBXO4
FBXO7
FBXW2
FOXO1
G0S2
H3C1
H4C1
HACE1
HECTD1
HECTD3
HECTD4
HECW1
HECW2
HERC1
HERC2
HERC4
HERC5
HUWE1
ILF3
ITCH
KAT2B
KCMF1
LNX1
LNX2
LRSAM1
LTN1
MAEA
MAP3K1
MAPT
MARCHF3
MARCHF5
MARCHF6
MARCHF7
MDM2
MDM4
MEX3A
MEX3C
MGRN1
MIB1
MIB2
MID1
MID2
MKRN3
MUL1
MYCBP2
MYLIP
NAT10
NBR1
NEDD4
NEDD4L
NFKBIA
NPR1
NSMCE1
OTUB1
PDZRN3
PELI1
PER2
PHF7
PHRF1
PJA1
PJA2
POLL
POLM
PRKN
QSOX1
RAD18
RAF1
RAG1
RBCK1
RBX1
RC3H1
RC3H2
RCHY1
RELA
RFFL
RFWD3
RING1
RLIM
RMND5A
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF125
RNF126
RNF13
RNF130
RNF135
RNF138
RNF14
RNF146
RNF150
RNF151
RNF166
RNF167
RNF168
RNF170
RNF181
RNF185
RNF186
RNF19A
RNF19B
RNF2
RNF20
RNF213
RNF216
RNF220
RNF224
RNF25
RNF26
RNF31
RNF34
RNF38
RNF4
RNF40
RNF43
RNF5
RNF7
RNF8
RSPRY1
RTF2
SIAH1
SIAH2
SMURF1
SMURF2
SNCA
SOCS6
SPOP
SQSTM1
STAM2
STK11
STUB1
SYVN1
TOPORS
TRAF2
TRAF6
TRAF7
TRAIP
TRIM10
TRIM13
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM33
TRIM35
TRIM36
TRIM37
TRIM38
TRIM39
TRIM41
TRIM43
TRIM45
TRIM46
TRIM47
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM65
TRIM7
TRIM8
TRIP12
TTC3
UBA1
UBA3
UBA5
UBA6
UBASH3B
UBB
UBC
UBD
UBE3A
UBE3C
UBE4A
UBE4B
UBOX5
UBR1
UBR2
UBR3
UBR4
UBR5
UBTD1
UFM1
UHRF2
UVSSA
VHL
VPS11
VPS18
WRN
WSB1
WWP1
WWP2
XIAP
ZNRF1
ZNRF2
ZNRF4
261 interacting genes:
ABL1
ABL2
ADRB2
AKAP5
AKT1
ANKRD17
APEX1
APP
AR
ARRB1
ARRB2
ATF4
ATM
ATP2A2
ATRX
AURKA
BAIAP2L1
BRINP1
BTK
BTRC
CANX
CASP2
CASP3
CCAR1
CCNG1
CDC34
CDH1
CDKN2A
CHEK2
CLSTN1
CLU
COPS5
CREBBP
CSNK2A1
CSNK2A2
CSNK2B
CTBP2
CWC25
DAPK1
DAPK3
DAXX
DDX24
DDX42
DHFR
DLG4
DNAJB4
DYRK2
E2F1
EGLN3
EID1
EP300
ESR1
EZR
F3
FBXO31
FHL2
FKBP1A
FOS
FOXO1
FOXO3
G3BP2
GADD45A
GCAT
GLIS2
GNL3
GORAB
GRK2
GSK3B
GTF2E2
GYS2
H2BC21
H3-4
HCK
HDAC1
HEY1
HIF1A
HIPK2
HLA-DMB
HMGA2
HMGN1
HNRNPK
HSP90B1
IER3
IGF1R
IRF1
IRF2
JMY
JUN
JUND
KAT2B
KAT5
KPNA1
LMO7
MAGEA2
MAP1LC3A
MAP2
MAPKAPK2
MDM4
MED1
MKRN3
MS4A1
MTBP
MYC
MYD88
MYDGF
NACA
NAT10
NCL
NDUFS1
NGFR
NOLC1
NOP53
NOTCH1
NPIPB3
NPM1
NR3C1
NUCKS1
NUMB
PAK6
PBX1
PBXIP1
PDE4D
PDIA3
PDLIM7
PDS5A
PER2
PGAM2
PHF7
PHLDB3
PIAS1
PJA1
PKM
PLK1
PML
POLE
POT1
PPIB
PPM1D
PPP1R10
PRDM2
PRKN
PSMA3
PSMC5
PSMD10
PSMD4
PSME3
PTK2
RAB8A
RAD23A
RANBP1
RANBP2
RARA
RASSF1
RB1
RBBP6
RBM10
RBM38
RCHY1
RESF1
RIDA
RLIM
RNF10
RNF126
RNF8
RPL11
RPL22
RPL26
RPL36A
RPL4
RPL5
RPS23
RPS27A
RPS3
RPS5
RRM2B
RRP1
RSL1D1
RUVBL2
RYBP
RYR2
S100A1
S100A2
S100A4
S100A6
S100B
SDHC
SENP3
SESN2
SET
SETD7
SETDB1
SHPK
SIRT2
SIRT3
SMARCA2
SMARCA4
SMARCE1
SMG7
SORBS2
SRC
SREK1
SRSF11
STK11
SUMO1
TAF1
TBP
TCAP
TERT
TFIP11
TOP1
TP53
TP53I3
TP53RK
TP73
TPR
TPT1
TRAF5
TRIM13
TRIM23
TRIM27
TRIM4
TRIM9
TSG101
UBB
UBC
UBE2A
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2J2
UBE2K
UBE2L3
UBE2N
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
UBE2S
UBE2U
UBE2Z
UBE3A
UBQLN4
UBTF
USP15
USP2
USP7
VEGFA
WRN
WT1
XBP1
XIAP
XPC
YY1AP1
ZNF133
ZNF420
Entrez ID
7322
4193
HPRD ID
04268
01272
Ensembl ID
ENSG00000131508
ENSG00000135679
Uniprot IDs
P62837
A0A0A8KB75
A7UKX7
A7UKX8
A7UKX9
G3XA89
Q00987
Q96DS0
PDB IDs
1UR6
1W4U
2CLW
2ESK
2ESO
2ESP
2ESQ
3A33
3JVZ
3JW0
3L1Y
3TGD
3ZNI
4A49
4A4B
4A4C
4AUQ
4DDG
4DDI
4LDT
4V3K
4V3L
4WZ3
5D0K
5D0M
5D1K
5D1L
5D1M
5EDV
5MNJ
5ULF
5ULH
5ULK
5VZW
5ZBU
6HPR
6SQO
6SQR
6SQS
6TTU
6W7Z
6W9D
1RV1
1T4E
1T4F
1YCR
1Z1M
2AXI
2C6A
2C6B
2F1Y
2FOP
2GV2
2HDP
2LZG
2M86
2MPS
2RUH
2VJE
2VJF
3EQS
3G03
3IUX
3IWY
3JZK
3JZR
3JZS
3LBK
3LBL
3LNJ
3LNZ
3MQS
3TJ2
3TPX
3TU1
3V3B
3VBG
3VZV
3W69
4DIJ
4ERE
4ERF
4HBM
4HFZ
4HG7
4JV7
4JV9
4JVE
4JVR
4JWR
4MDN
4MDQ
4OAS
4OBA
4OCC
4ODE
4ODF
4OGN
4OGT
4OGV
4OQ3
4QO4
4QOC
4UD7
4UE1
4UMN
4WT2
4XXB
4ZFI
4ZGK
4ZYC
4ZYF
4ZYI
5AFG
5C5A
5HMH
5HMI
5HMK
5J7F
5J7G
5LAV
5LAW
5LAY
5LAZ
5LN2
5MNJ
5OAI
5OC8
5SWK
5TRF
5UMM
5VK0
5WTS
5XXK
5Z02
5ZXF
6AAW
6GGN
6H22
6HFA
6I29
6I3S
6IM9
6KZU
6Q96
6Q9H
6Q9L
6Q9O
6SQO
6T2D
6T2E
6T2F
6Y4Q
7AD0
Enriched GO Terms of Interacting Partners
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