TOP2A and DFFB

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TOP2A	DFFB
Description		DNA topoisomerase II alpha	DNA fragmentation factor subunit beta
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Centriole DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Protein-containing Complex Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Protein-containing Complex
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding RNA Binding DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity DNA Binding, Bending Enzyme Binding Protein Homodimerization Activity Histone Deacetylase Binding Ubiquitin Binding Protein Heterodimerization Activity	Deoxyribonuclease Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Disordered Domain Specific Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Topological Change DNA Ligation Cellular Response To DNA Damage Stimulus Chromosome Segregation Female Meiotic Nuclear Division Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of DNA Duplex Unwinding	DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Chromosome Condensation
Pathways		Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins	Apoptosis induced DNA fragmentation
Drugs		Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Dactinomycin Lomefloxacin Doxorubicin Norfloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone Banoxantrone SP1049C Amonafide Elsamitrucin 13-deoxydoxorubicin RTA 744 Aldoxorubicin ZEN-012 Amrubicin Becatecarin Annamycin Declopramide Finafloxacin
Diseases
GWAS		Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Neutrophil percentage of white cells ( 32888494)	Blood trace element (Cu levels) ( 23720494) Metabolite levels ( 23823483)
Interacting Genes		29 interacting genes: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 FBXO28 HDAC1 HDAC2 JUN MAPK1 PIAS4 PIN1 PLK1 PRKCA PRKCB PRKCG RB1 RNF168 SMURF2 SRPK1 SUMO1 SUMO2 SUMO4 TOP2B TP53 UBE2I XPO1 YWHAE	4 interacting genes: APP CIDEB DFFA TOP2A
Entrez ID		7153	1677
HPRD ID		00536	03532
Ensembl ID		ENSG00000131747	ENSG00000169598
Uniprot IDs		P11388	B4DZS0 O76075 Q96P72 Q96P73 Q96P74
PDB IDs		1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE	1IBX
Enriched GO Terms of Interacting Partners?
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