TOP2A and SUMO4

Data Source:
HPRD (in vivo)

		TOP2A	SUMO4
Description		DNA topoisomerase II alpha	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Centriole DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Protein-containing Complex Ribonucleoprotein Complex	Nucleus SUMO Ligase Complex
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding RNA Binding DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity DNA Binding, Bending Enzyme Binding Protein Homodimerization Activity Histone Deacetylase Binding Ubiquitin Binding Protein Heterodimerization Activity	Molecular_function Protein Tag Ubiquitin-like Protein Ligase Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Topological Change DNA Ligation Cellular Response To DNA Damage Stimulus Chromosome Segregation Female Meiotic Nuclear Division Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of DNA Duplex Unwinding	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Localization To Nucleus
Pathways		Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins
Drugs		Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Dactinomycin Lomefloxacin Doxorubicin Norfloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone Banoxantrone SP1049C Amonafide Elsamitrucin 13-deoxydoxorubicin RTA 744 Aldoxorubicin ZEN-012 Amrubicin Becatecarin Annamycin Declopramide Finafloxacin
Diseases
GWAS		Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Neutrophil percentage of white cells ( 32888494)	Dupuytren's disease ( 28886342)
Interacting Genes		29 interacting genes: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 FBXO28 HDAC1 HDAC2 JUN MAPK1 PIAS4 PIN1 PLK1 PRKCA PRKCB PRKCG RB1 RNF168 SMURF2 SRPK1 SUMO1 SUMO2 SUMO4 TOP2B TP53 UBE2I XPO1 YWHAE	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		7153	387082
HPRD ID		00536	10584
Ensembl ID		ENSG00000131747	ENSG00000177688
Uniprot IDs		P11388	Q6EEV6
PDB IDs		1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE
Enriched GO Terms of Interacting Partners?
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