KDR and STYX

Data Source:
BioGRID (two hybrid)

		KDR	STYX
Description		kinase insert domain receptor	serine/threonine/tyrosine interacting protein
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Receptor Complex Membrane Raft Sorting Endosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Integrin Binding Protein Binding ATP Binding Growth Factor Binding Vascular Endothelial Growth Factor Binding Identical Protein Binding Cadherin Binding Hsp90 Protein Binding	Pseudophosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity F-box Domain Binding
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Hematopoietic Progenitor Cell Differentiation Endothelium Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Positive Regulation Of Macroautophagy Cell Migration Peptidyl-tyrosine Phosphorylation Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Kinase Activity Embryonic Hemopoiesis Calcium-mediated Signaling Using Intracellular Calcium Source Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Positive Chemotaxis Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Mitochondrial Depolarization Vascular Wound Healing ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Mitochondrial Fission Cellular Response To Hydrogen Sulfide Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis	Protein Dephosphorylation Negative Regulation Of Protein Binding Negative Regulation Of Catalytic Activity MAPK Export From Nucleus Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Regulation Of ERK1 And ERK2 Cascade
Pathways		Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization Integrin cell surface interactions VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Drugs		Sorafenib Sunitinib 1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea Cediranib Vatalanib XL999 TG-100801 XL820 CYC116 Ramucirumab Pegdinetanib RAF-265 ABT-869 IMC-1C11 Semaxanib Pazopanib Midostaurin Axitinib 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine Cabozantinib Regorafenib Ponatinib Lenvatinib Nintedanib Fostamatinib Erdafitinib Foretinib Ripretinib Pralsetinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Endometriosis ( 28537267) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FVC) ( 30804560) Mosquito bite size ( 28199695) Peak expiratory flow ( 30804560) Serum VEGFR2 concentration ( 25411163) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Prostate cancer ( 23535732)
Interacting Genes		60 interacting genes: ACP1 AIMP2 ANXA5 ATR BMX BTRC CAV1 CBL CCDC88A CDH5 COL18A1 CRK CSF2RB CSNK1D CTNNB1 DNM2 DUSP19 FBXO25 FBXW11 FLT1 FLT4 FRS2 FYN GABARAP GNA11 GNAQ GRB10 GRB2 HSP90AA1 ILKAP IQGAP1 ITGB3 MAPK1 NCK1 NRP1 P2RY2 PDCL3 PLCG1 PLCG2 PPM1A PPM1B PTPN11 PTPN12 PTPN6 PTPRR RASA1 SERPINF1 SH2D2A SHB SHC1 SHC2 SRC STAT1 STYX SYNGAP1 TIMP3 VEGFA VEGFC VEGFD YES1	24 interacting genes: AATK CARHSP1 EGFR EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 FBXO7 FBXW7 IGF1R INSR INSRR KDR KIT LMTK2 MAPK1 MUSK PTK7 ROR1 ROR2 TEK
Entrez ID		3791	6815
HPRD ID		01867	10258
Ensembl ID		ENSG00000128052	ENSG00000198252
Uniprot IDs		P35968	A0A024R641 Q8WUJ0
PDB IDs		1VR2 1Y6A 1Y6B 1YWN 2M59 2MET 2MEU 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 3WZD 3WZE 4AG8 4AGC 4AGD 4ASD 4ASE 5EW3 5OYJ 6GQO 6GQP 6GQQ 6XVJ 6XVK	2R0B
Enriched GO Terms of Interacting Partners?
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