NSD1 and PRKCD

Data Source:
BioGRID (genetic interference)

		NSD1	PRKCD
Description		nuclear receptor binding SET domain protein 1	protein kinase C delta
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Nuclear Matrix Azurophil Granule Lumen Endolysosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Kinase Binding Protein Kinase Binding Insulin Receptor Substrate Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K36 Methylation Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Regulation Of Peptidyl-serine Phosphorylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Signaling Receptor Activity Immunoglobulin Mediated Immune Response Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Termination Of Signal Transduction Platelet Activation Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Protein Binding Activation Of Protein Kinase Activity Positive Regulation Of Superoxide Anion Generation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Glial Cell Apoptotic Process Cellular Response To UV Positive Regulation Of Protein Dephosphorylation Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation Neutrophil Activation Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of MAP Kinase Activity Regulation Of MRNA Stability Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Negative Regulation Of Filopodium Assembly Cell Chemotaxis Interferon-gamma-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Hydroperoxide Negative Regulation Of Platelet Aggregation Cellular Senescence Positive Regulation Of Phospholipid Scramblase Activity Cellular Response To Angiotensin Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway
Pathways		PKMTs methylate histone lysines	Apoptotic cleavage of cellular proteins Calmodulin induced events Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events HuR (ELAVL1) binds and stabilizes mRNA VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Interferon gamma signaling
Drugs			Tamoxifen 13-Acetylphorbol Ingenol mebutate Fostamatinib
Diseases		Beckwith-Wiedemann syndrome Sotos syndrome and Weaver syndrome
GWAS		Activated partial thromboplastin time ( 22703881) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 25282103 31562340) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Narrowest width of the femoral neck ( 30888730) Neutrophil count ( 32888494) Nonsyndromic cleft lip ( 31609978) Urate levels ( 31578528) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bipolar disorder ( 21926972) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Ulcerative colitis ( 23128233) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		36 interacting genes: AGR2 AR ATRX CCDC125 CYSRT1 ESR1 ESRRA H1-2 H1-3 H1-5 H3-4 H3C1 H4-16 H4C1 HNF4G KRTAP6-2 MDFI NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 NTRK3 POLR2A PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496	120 interacting genes: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GRK2 GRM5 GSK3A H1-1 H1-5 HABP4 HDAC5 HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NOTCH1 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTPN22 PTPN6 PTPRA RAC1 RACK1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SPRY2 SQSTM1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP YWHAB YWHAG YWHAZ
Entrez ID		64324	5580
HPRD ID		09455	01501
Ensembl ID		ENSG00000165671	ENSG00000163932
Uniprot IDs		Q96L73 Q96MN8	A0A024R328 B4DFV1 Q05655
PDB IDs		3OOI 6KQP 6KQQ	1YRK 2YUU
Enriched GO Terms of Interacting Partners?
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