NSD1 and NR2E1

Data Source:
BioGRID (two hybrid)

		NSD1	NR2E1
Description		nuclear receptor binding SET domain protein 1	nuclear receptor subfamily 2 group E member 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K36 Methylation Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Regulation Of Peptidyl-serine Phosphorylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Aggressive Behavior Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Visual Perception Dentate Gyrus Development Amygdala Development Olfactory Bulb Development Layer Formation In Cerebral Cortex Forebrain Generation Of Neurons Cerebral Cortex Neuron Differentiation Anterior Commissure Morphogenesis Cell Differentiation Extracellular Matrix Organization Intracellular Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Social Behavior Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Astrocyte Differentiation Regulation Of Dendrite Morphogenesis Anatomical Structure Development Retina Development In Camera-type Eye Regulation Of Timing Of Neuron Differentiation Long-term Synaptic Potentiation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		PKMTs methylate histone lysines	Nuclear Receptor transcription pathway Regulation of PTEN gene transcription
Drugs
Diseases		Beckwith-Wiedemann syndrome Sotos syndrome and Weaver syndrome
GWAS		Activated partial thromboplastin time ( 22703881) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 25282103 31562340) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Narrowest width of the femoral neck ( 30888730) Neutrophil count ( 32888494) Nonsyndromic cleft lip ( 31609978) Urate levels ( 31578528) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		36 interacting genes: AGR2 AR ATRX CCDC125 CYSRT1 ESR1 ESRRA H1-2 H1-3 H1-5 H3-4 H3C1 H4-16 H4C1 HNF4G KRTAP6-2 MDFI NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 NTRK3 POLR2A PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496	6 interacting genes: ATN1 DNMT3L ERBIN KDM1A NSD1 RERE
Entrez ID		64324	7101
HPRD ID		09455	07230
Ensembl ID		ENSG00000165671	ENSG00000112333
Uniprot IDs		Q96L73 Q96MN8	B6ZGT9 Q9Y466
PDB IDs		3OOI 6KQP 6KQQ	4XAJ
Enriched GO Terms of Interacting Partners?
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