PDLIM2 and BCAR3

Data Source:
BioGRID (two hybrid)

		PDLIM2	BCAR3
Description		PDZ and LIM domain 2	BCAR3 adaptor protein, NSP family member
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GO Annotations	Cellular Component	Stress Fiber Nucleus Adherens Junction Z Disc Filamentous Actin	Cytoplasm Focal Adhesion Membrane
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Muscle Structure Development	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelin Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Parkinson's disease ( 28892059) Platelet count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Survival in breast cancer (estrogen-receptor positive) ( 29423119)	Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Liver fibrosis (total hepatic collagen content) ( 32953199) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)
Interacting Genes		13 interacting genes: ACD APC AURKA BAG4 BCAR3 FGFR2 FGFR4 MKRN2 POT1 RAF1 TGFB1 UBE2E2 ZNF695	38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GAS8 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45
Entrez ID		64236	8412
HPRD ID		17831	05268
Ensembl ID		ENSG00000120913	ENSG00000137936
Uniprot IDs		Q96JY6	A0A384MTS3 B3KNL6 B3KP06 O75815
PDB IDs		2PA1 3PDV	3T6A
Enriched GO Terms of Interacting Partners?
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