SEMA4A and DDX54

Data Source:
BioGRID (two hybrid)

		SEMA4A	DDX54
Description		semaphorin 4A	DEAD-box helicase 54
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleoplasm Nucleolus Golgi Apparatus Membrane
	Molecular Function	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity	Transcription Corepressor Activity RNA Binding RNA Helicase Activity Signaling Receptor Binding ATP Binding Estrogen Receptor Binding
	Biological Process	Angiogenesis Neural Crest Cell Migration Axon Guidance Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration T-helper 1 Cell Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Semaphorin-plexin Signaling Pathway Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Inhibitory Synapse Assembly	RRNA Processing RNA Processing RNA Metabolic Process Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Pathways		Other semaphorin interactions
Drugs
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Retinitis pigmentosa (RP)
GWAS		Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Stroke ( 29531354) Systolic blood pressure ( 30224653)	Body mass index ( 26426971) Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		3 interacting genes: DDX54 HAVCR1 PLXND1	19 interacting genes: APP CASK CSNK2A1 DVL3 DYNLT1 ESR1 ESR2 NEDD4 NEDD4L NR3C1 PGR PJA1 POLR2G PTPRD SEMA4A SMURF1 TMED9 YWHAE ZNF394
Entrez ID		64218	79039
HPRD ID		09528	13129
Ensembl ID		ENSG00000196189	ENSG00000123064
Uniprot IDs		B4DKS5 Q9H3S1	Q8TDD1
PDB IDs
Enriched GO Terms of Interacting Partners?
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