SEMA4A and PLXND1

Data Source:
HPRD (in vitro, in vivo)

		SEMA4A	PLXND1
Description		semaphorin 4A	plexin D1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Lamellipodium Lamellipodium Membrane
	Molecular Function	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding
	Biological Process	Angiogenesis Neural Crest Cell Migration Axon Guidance Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration T-helper 1 Cell Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Semaphorin-plexin Signaling Pathway Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Inhibitory Synapse Assembly	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Kidney Development Outflow Tract Morphogenesis Cardiac Septum Development Negative Regulation Of Cell Adhesion Positive Regulation Of Transcription Of Notch Receptor Target Synapse Assembly Regulation Of Cell Shape Regulation Of Cell Migration Positive Regulation Of Protein Binding Aorta Development Regulation Of GTPase Activity Endothelial Cell Migration Regulation Of Angiogenesis Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Coronary Vasculature Development Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Pathways		Other semaphorin interactions	Other semaphorin interactions NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Retinitis pigmentosa (RP)
GWAS		Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Stroke ( 29531354) Systolic blood pressure ( 30224653)	Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		3 interacting genes: DDX54 HAVCR1 PLXND1	3 interacting genes: HOXB5 MACF1 SEMA4A
Entrez ID		64218	23129
HPRD ID		09528	05046
Ensembl ID		ENSG00000196189	ENSG00000004399
Uniprot IDs		B4DKS5 Q9H3S1	Q9Y4D7
PDB IDs			3H6N
Enriched GO Terms of Interacting Partners?
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