CCL1 and CCR8

Data Source:
HPRD (in vitro, in vivo)

		CCL1	CCR8
Description		C-C motif chemokine ligand 1	C-C motif chemokine receptor 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Chemokine Activity CCR Chemokine Receptor Binding	Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Neutrophil Chemotaxis Positive Regulation Of Interleukin-17 Production Positive Regulation Of GTPase Activity Eosinophil Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Inflammatory Response Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Monocyte Chemotaxis	Chemotaxis Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)	Daytime sleep phenotypes ( 27126917) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		3 interacting genes: CCR8 CXCL11 HUWE1	19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1
Entrez ID		6346	1237
HPRD ID		01654	03497
Ensembl ID		ENSG00000108702	ENSG00000179934
Uniprot IDs		P22362	P51685
PDB IDs		1EL0 4OIJ 4OIK
Enriched GO Terms of Interacting Partners?
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