SCNN1B and SCNN1D

Data Source:
HPRD (in vivo)

		SCNN1B	SCNN1D
Description		sodium channel epithelial 1 subunit beta	sodium channel epithelial 1 subunit delta
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Sodium Channel Complex Extracellular Exosome Plasma Membrane Protein Complex	Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton Membrane Sodium Channel Complex
	Molecular Function	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Protein Binding Ligand-gated Sodium Channel Activity
	Biological Process	Sodium Ion Transport Excretion Gene Expression Artery Smooth Muscle Contraction Ion Transmembrane Transport Sodium Ion Transmembrane Transport Epithelial Fluid Transport Response To Drug Multicellular Organismal Water Homeostasis Sensory Perception Of Taste Sodium Ion Homeostasis Cellular Response To Aldosterone	Sodium Ion Transport Ion Transmembrane Transport Sodium Ion Transmembrane Transport Response To Stimulus Sensory Perception Of Taste
Pathways		Stimuli-sensing channels	Stimuli-sensing channels
Drugs		Triamterene Amiloride	Triamterene Amiloride
Diseases		Liddle syndrome Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Bronchiectasis with or without elevated sweat chloride
GWAS		Kidney stones ( 31729369)	Inflammatory bowel disease ( 28067908) Platelet count ( 24777453) Ulcerative colitis ( 28067908)
Interacting Genes		14 interacting genes: ANK3 CNTN1 COMMD10 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2	2 interacting genes: SCNN1B SCNN1G
Entrez ID		6338	6339
HPRD ID		02861	03209
Ensembl ID		ENSG00000168447	ENSG00000162572
Uniprot IDs		B2R812 P51168	P51172
PDB IDs		6BQN 6WTH
Enriched GO Terms of Interacting Partners?
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