SCNN1B and CNTN1

Data Source:
HPRD (in vivo)

		SCNN1B	CNTN1
Description		sodium channel epithelial 1 subunit beta	contactin 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Sodium Channel Complex Extracellular Exosome Plasma Membrane Protein Complex	Membrane Membrane Raft Extracellular Exosome Anchored Component Of Postsynaptic Membrane Anchored Component Of Presynaptic Membrane
	Molecular Function	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Protein Binding Carbohydrate Binding
	Biological Process	Sodium Ion Transport Excretion Gene Expression Artery Smooth Muscle Contraction Ion Transmembrane Transport Sodium Ion Transmembrane Transport Epithelial Fluid Transport Response To Drug Multicellular Organismal Water Homeostasis Sensory Perception Of Taste Sodium Ion Homeostasis Cellular Response To Aldosterone	Cell Adhesion Notch Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development Neuron Projection Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Pathways		Stimuli-sensing channels	Activated NOTCH1 Transmits Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus L1CAM interactions Neurofascin interactions
Drugs		Triamterene Amiloride
Diseases		Liddle syndrome Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Bronchiectasis with or without elevated sweat chloride
GWAS		Kidney stones ( 31729369)	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Blood protein levels ( 30072576) Body mass index ( 26426971) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Metabolite levels (X-11787) ( 23934736) Motion sickness ( 25628336) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pneumoconiosis in silica exposure ( 24986923) Protein quantitative trait loci ( 18464913)
Interacting Genes		14 interacting genes: ANK3 CNTN1 COMMD10 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2	14 interacting genes: CNTN2 FYN GPR37 L1CAM MAPK6 NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCN3A SCNN1B TNC TNR
Entrez ID		6338	1272
HPRD ID		02861	07189
Ensembl ID		ENSG00000168447	ENSG00000018236
Uniprot IDs		B2R812 P51168	A0A024R104 Q12860
PDB IDs		6BQN 6WTH	2EE2 3S97
Enriched GO Terms of Interacting Partners?
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