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SCNN1B and ITCH
Data Source:
BioGRID
(far western blotting)
SCNN1B
ITCH
Description
sodium channel epithelial 1 subunit beta
itchy E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle Membrane
Sodium Channel Complex
Extracellular Exosome
Plasma Membrane Protein Complex
Nucleoplasm
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Protein Binding
Ligand-gated Sodium Channel Activity
WW Domain Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Ribonucleoprotein Complex Binding
Ubiquitin-like Protein Ligase Binding
CXCR Chemokine Receptor Binding
Ubiquitin Protein Ligase Activity
Arrestin Family Protein Binding
Biological Process
Sodium Ion Transport
Excretion
Gene Expression
Artery Smooth Muscle Contraction
Ion Transmembrane Transport
Sodium Ion Transmembrane Transport
Epithelial Fluid Transport
Response To Drug
Multicellular Organismal Water Homeostasis
Sensory Perception Of Taste
Sodium Ion Homeostasis
Cellular Response To Aldosterone
Protein Polyubiquitination
Regulation Of Cell Growth
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Inflammatory Response
Notch Signaling Pathway
Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Protein K29-linked Ubiquitination
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of JNK Cascade
Viral Entry Into Host Cell
Negative Regulation Of Defense Response To Virus
Defense Response To Virus
Protein Autoubiquitination
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Protein Deubiquitination
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Receptor Catabolic Process
Pathways
Stimuli-sensing channels
Downregulation of ERBB4 signaling
NOD1/2 Signaling Pathway
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Triamterene
Amiloride
Diseases
Liddle syndrome
Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
Bronchiectasis with or without elevated sweat chloride
GWAS
Kidney stones (
31729369
)
Bipolar disorder (
31043756
)
Colorectal cancer or advanced adenoma (
30510241
)
Estimated glomerular filtration rate (
31152163
31015462
)
Fish- and plant-related diet (
32066663
)
Heel bone mineral density (
28869591
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Vitiligo (
27723757
)
Interacting Genes
14 interacting genes:
ANK3
CNTN1
COMMD10
EPN1
HECW1
ITCH
NEDD4
NEDD4L
NFASC
SCNN1A
SCNN1D
SCNN1G
STX1A
WWP2
103 interacting genes:
ARHGEF7
ARID1A
ARRB2
ARRDC3
ATN1
BECN1
BIN1
BRAF
CBL
CBLC
CDC34
CPSF6
CPSF7
CSNK2A1
CXCR4
CYLD
DAZAP1
DTX1
DTX3L
ERBB4
EWSR1
FYN
GLIS3
GNAI2
HNRNPL
HNRNPUL1
JUN
JUNB
KPNB1
LAPTM5
LITAF
LRRK1
MAP2K4
MAPK8
MARVELD2
MLANA
N4BP1
NDFIP1
NDFIP2
NEDD9
NFE2
NOTCH1
NUDT21
NUMB
PABPC1
PACSIN1
POLR2A
POLR2B
POLR2C
POLR2E
POU5F1
PRKACA
RASSF5
RIPK1
RNF11
RPAP2
RPAP3
SCNN1A
SCNN1B
SF1
SGK3
SH3GL1
SH3GL2
SMAD2
SMAD3
SMARCC1
SMARCC2
SMARCE1
SMN1
SNX9
SPART
STAM2
SUFU
TAB1
TP63
TP73
TRPC4
TRPV1
TRPV4
TXNIP
UBAP2
UBAP2L
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2J2
UBE2K
UBE2L3
UBE2M
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
URI1
WASL
WBP2
Entrez ID
6338
83737
HPRD ID
02861
07565
Ensembl ID
ENSG00000168447
ENSG00000078747
Uniprot IDs
B2R812
P51168
A0A590UJQ1
Q96J02
PDB IDs
6BQN
6WTH
2DMV
2KYK
2NQ3
2P4R
2YSF
3TUG
4ROF
5C7M
5CQ2
5DWS
5DZD
5SXP
Enriched GO Terms of Interacting Partners
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