SHANK1 and ADGRB2

Data Source:
HPRD (two hybrid)

		SHANK1	ADGRB2
Description		SH3 and multiple ankyrin repeat domains 1	adhesion G protein-coupled receptor B2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Neuron Projection Dendritic Spine Postsynaptic Membrane Excitatory Synapse	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Behavior Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Brain Morphogenesis Neuromuscular Process Controlling Balance Determination Of Affect Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Maturation Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Peripheral Nervous System Development Negative Regulation Of Angiogenesis Calcineurin-NFAT Signaling Cascade
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)	Asthma ( 31959851) Intraocular pressure ( 29617998 29785010) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		19 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 USP8	8 interacting genes: ARHGAP1 GABPB1 HDHD2 LRP2BP SHANK1 SHANK2 SNTA1 STARD13
Entrez ID		50944	576
HPRD ID		05413	04063
Ensembl ID		ENSG00000161681	ENSG00000121753
Uniprot IDs		H9KV90 Q9Y566	O60241
PDB IDs		6CPI
Enriched GO Terms of Interacting Partners?
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