RPGR and PDE6D

Data Source:
HPRD (in vitro, two hybrid)

		RPGR	PDE6D
Description		retinitis pigmentosa GTPase regulator	phosphodiesterase 6D
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Golgi Apparatus Centrosome Ciliary Basal Body Sperm Flagellum	Cytoplasm Cytosol Cytoskeleton Cilium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Inhibitor Activity Protein Binding Small GTPase Binding
	Biological Process	Intracellular Protein Transport Visual Perception Intraciliary Transport Regulation Of Catalytic Activity Response To Stimulus Cilium Assembly	Visual Perception Negative Regulation Of GTPase Activity Response To Stimulus
Pathways			ARL13B-mediated ciliary trafficking of INPP5E RAS processing
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Retinitis pigmentosa (RP)
GWAS			Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Interacting Genes		14 interacting genes: DCTN1 DCTN2 HOMEZ IFT88 KIF3A KIFAP3 NPM1 PDE6D RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE	25 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS OTP PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR
Entrez ID		6103	5147
HPRD ID		02425	04056
Ensembl ID		ENSG00000156313	ENSG00000156973
Uniprot IDs		Q92834	B8ZZK5 O43924 Q6IB24
PDB IDs		4JHN 4JHP 4QAM	1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW
Enriched GO Terms of Interacting Partners?
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