UBE2E2 and DTX3L

Data Source:
BioGRID (two hybrid)

		UBE2E2	DTX3L
Description		ubiquitin conjugating enzyme E2 E2	deltex E3 ubiquitin ligase 3L
Image
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Early Endosome Cytosol Early Endosome Membrane Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity STAT Family Protein Binding
	Biological Process	Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Protein Phosphopantetheinylation ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Polyubiquitination Positive Regulation Of Defense Response To Virus By Host Double-strand Break Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Notch Signaling Pathway Endosome To Lysosome Transport Histone Monoubiquitination Protein Transport Viral Process Protein Ubiquitination Positive Regulation Of Protein Binding Histone H2A Ubiquitination Histone H2B Ubiquitination Positive Regulation Of Chromatin Binding Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Ubiquitin-protein Transferase Activity Defense Response To Virus Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Receptor Catabolic Process Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma ( 32296059) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Motion sickness ( 25628336) Physiological dysregulation (Mahalanobis distance) ( 32235003) Psychosis (atypical) ( 24132900) Red blood cell count ( 32888494) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Seasonality and depression ( 30217971) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 23945395 32499647 30718926 28869590) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Vitiligo ( 27723757)	Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 22472876)
Interacting Genes		75 interacting genes: APP ARIH1 ARIH2 ARRDC3 ASXL2 BARD1 BRCA1 CBL CHFR CUEDC1 CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B IPO11 ITCH MARCHF3 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFE2L2 OTUB1 PCGF2 PDLIM2 PGPEP1 PRAM1 PRKN RBX1 RC3H2 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF14 RNF166 RNF185 RNF19A RNF2 RNF25 RNF31 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBOX5 WWP2 XIAP ZNRF1	20 interacting genes: DTX1 H2AZ2 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W
Entrez ID		7325	151636
HPRD ID		06779	16843
Ensembl ID		ENSG00000182247	ENSG00000163840
Uniprot IDs		Q96LR5	Q8TDB6
PDB IDs		1Y6L 6W9A	3PG6
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?