RBP3 and HSD3B7

Data Source:
BioGRID (two hybrid)

		RBP3	HSD3B7
Description		retinol binding protein 3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cone Matrix Sheath Extracellular Vesicle	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane
	Molecular Function	Retinoid Binding Protein Binding Serine-type Peptidase Activity Retinal Binding Retinol Binding	3-beta-hydroxy-delta5-steroid Dehydrogenase Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity
	Biological Process	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Visual Perception	Bile Acid Biosynthetic Process B Cell Chemotaxis
Pathways		The retinoid cycle in cones (daylight vision) The canonical retinoid cycle in rods (twilight vision)	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs		Lapachone
Diseases			Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC) Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS		Corneal curvature ( 24963161) Macular thickness ( 30535121)
Interacting Genes		15 interacting genes: CDC23 CREB5 CYSRT1 EFEMP2 HOXA1 HR HSD3B7 KPRP KRTAP10-5 MGAT5B NID2 NOTCH1 PLSCR4 POU4F2 SPAG8	58 interacting genes: ADAMTSL4 AGR2 ANAPC11 APPBP2 ARID5A ASB12 BTN2A2 C22orf39 COMT CREB5 CYSRT1 DAPP1 EFEMP1 EFEMP2 EGFL7 ELOVL4 EMG1 FBLN2 GLRX3 HOXA1 HSD17B13 ICAM1 KPNA4 KPRP KRT31 KRT40 KRT86 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-2 KRTAP4-2 KRTAP5-9 LCE4A LINGO1 MEI4 MEOX2 MGAT5B NOTCH2NLA NR4A3 OTX2 PYGL RBP3 REEP4 RGS17 RUSF1 SPRY2 SSC4D TMEM31 TMX2 TRIM42 YPEL3 ZBTB42 ZNF655
Entrez ID		5949	80270
HPRD ID		01581	09680
Ensembl ID		ENSG00000265203	ENSG00000099377
Uniprot IDs		P10745	Q9H2F3
PDB IDs
Enriched GO Terms of Interacting Partners?
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