SENP2 and TPD52

Data Source:
BioGRID (two hybrid)

		SENP2	TPD52
Description		SUMO specific peptidase 2	tumor protein D52
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytosol PML Body Nuclear Membrane	Cytoplasm Endoplasmic Reticulum Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding SUMO-specific Protease Activity Protein Domain Specific Binding SUMO-specific Endopeptidase Activity SUMO-specific Isopeptidase Activity	Calcium Ion Binding Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Heart Development Dorsal/ventral Axis Specification Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Negative Regulation Of Protein Binding Regulation Of DNA Endoreduplication Negative Regulation Of Chromatin Binding Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Regulation Of G1/S Transition Of Mitotic Cell Cycle	Anatomical Structure Morphogenesis B Cell Differentiation Secretion
Pathways		SUMO is proteolytically processed	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Diastolic blood pressure ( 28135244 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 31015462) Height ( 28552196) Hip circumference ( 28552196) JT interval ( 29874175) PR interval ( 30046033 32439900) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 27841878 26969751)	Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 31361310 31959851 27182965 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Lapatinib-induced hepatotoxicity ( 25987243) Metabolite levels (HVA/MHPG ratio) ( 23319000) Metabolite levels (Pyroglutamine) ( 23934736) Rheumatoid arthritis ( 30423114 24390342) Self-reported allergy ( 23817569)
Interacting Genes		38 interacting genes: ACSF2 AGTRAP APOC2 APOC4 APP ARL6IP1 ARMC12 AXIN1 CDCA5 CDK5RAP2 DAXX ERCC6 FUNDC1 FZR1 HCCS IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 PML RANGAP1 RETREG3 RPRM SDR16C5 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TNFRSF10D TPD52 TRIM63	14 interacting genes: ANXA6 AR MAL2 SENP2 SH3GLB1 SOCS2 SPG21 SRPK2 STUB1 THAP4 TPD52L1 TPD52L2 TPD52L3 TTPA
Entrez ID		59343	7163
HPRD ID		07002	04963
Ensembl ID		ENSG00000163904	ENSG00000076554
Uniprot IDs		Q9HC62	P55327
PDB IDs		1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK
Enriched GO Terms of Interacting Partners?
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