SENP2 and CDK5RAP2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SENP2	CDK5RAP2
Description		SUMO specific peptidase 2	CDK5 regulatory subunit associated protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytosol PML Body Nuclear Membrane	Pericentriolar Material Spindle Pole Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Gamma-tubulin Ring Complex Cell Junction Microtubule Plus-end Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle Pole
	Molecular Function	Protein Binding SUMO-specific Protease Activity Protein Domain Specific Binding SUMO-specific Endopeptidase Activity SUMO-specific Isopeptidase Activity	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Gamma-tubulin Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Heart Development Dorsal/ventral Axis Specification Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Negative Regulation Of Protein Binding Regulation Of DNA Endoreduplication Negative Regulation Of Chromatin Binding Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Regulation Of G1/S Transition Of Mitotic Cell Cycle	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Chromosome Segregation Centrosome Cycle Centriole Replication Brain Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Neurogenesis Microtubule Organizing Center Organization Positive Regulation Of Microtubule Polymerization Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Ciliary Basal Body-plasma Membrane Docking
Pathways		SUMO is proteolytically processed	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases			Primary microcephaly (MCPH)
GWAS		Diastolic blood pressure ( 28135244 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 31015462) Height ( 28552196) Hip circumference ( 28552196) JT interval ( 29874175) PR interval ( 30046033 32439900) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 27841878 26969751)	Asthma ( 27611488) Height ( 28552196) Photic sneeze reflex ( 27182965) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 24782177)
Interacting Genes		38 interacting genes: ACSF2 AGTRAP APOC2 APOC4 APP ARL6IP1 ARMC12 AXIN1 CDCA5 CDK5RAP2 DAXX ERCC6 FUNDC1 FZR1 HCCS IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 PML RANGAP1 RETREG3 RPRM SDR16C5 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TNFRSF10D TPD52 TRIM63	25 interacting genes: ABCA2 CDK5 CDK5R1 CLIP4 CRMP1 EEF1G ERG28 FBXO25 HAP1 KAT5 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1
Entrez ID		59343	55755
HPRD ID		07002	09740
Ensembl ID		ENSG00000163904	ENSG00000136861
Uniprot IDs		Q9HC62	A0A0A0MRG9 B3KVI2 B9EG74 Q7Z3M0 Q96SN8
PDB IDs		1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK
Enriched GO Terms of Interacting Partners?
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