PLEKHA2 and DLG3

Data Source:
BioGRID (two hybrid)

		PLEKHA2	DLG3
Description		pleckstrin homology domain containing A2	discs large MAGUK scaffold protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Protein-containing Complex	Extracellular Space Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Basolateral Plasma Membrane Cell Junction
	Molecular Function	Fibronectin Binding Protein Binding Lipid Binding PDZ Domain Binding Laminin Binding Phosphatidylinositol-3,4-bisphosphate Binding	Protein Binding Kinase Binding Phosphatase Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Phosphatidylinositol Biosynthetic Process	MAPK Cascade Negative Regulation Of Cell Population Proliferation Embryo Development Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of NMDA Receptor Activity
Pathways		Synthesis of PIPs at the plasma membrane	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		High density lipoprotein cholesterol levels ( 31211820) Monocyte percentage of white cells ( 32888494)	Mean platelet volume ( 32888494)
Interacting Genes		19 interacting genes: COG6 DLG2 DLG3 EGLN3 FHL5 GIPC1 GIPC2 GIPC3 GOLGA2 HSF2BP KANK2 LNX1 M1AP MPDZ PLEKHA1 PTPN13 SNTG1 TEPSIN TRIM23	48 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OSBP2 PLEKHA2 PTK2B RPS8 SCN4A SCN5A SEMA4C SYNGAP1 VTN
Entrez ID		59339	1741
HPRD ID			02177
Ensembl ID		ENSG00000169499	ENSG00000082458
Uniprot IDs		A0A087WZ32 A8K727 Q9HB19	Q59FY1 Q92796
PDB IDs			1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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