PLEKHA2 and GIPC1

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		PLEKHA2	GIPC1
Description		pleckstrin homology domain containing A2	GIPC PDZ domain containing family member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Protein-containing Complex	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Fibronectin Binding Protein Binding Lipid Binding PDZ Domain Binding Laminin Binding Phosphatidylinositol-3,4-bisphosphate Binding	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Identical Protein Binding Cadherin Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Phosphatidylinositol Biosynthetic Process	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Regulation Of Synaptic Vesicle Exocytosis
Pathways		Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 31211820) Monocyte percentage of white cells ( 32888494)	Kidney stones ( 31729369)
Interacting Genes		19 interacting genes: COG6 DLG2 DLG3 EGLN3 FHL5 GIPC1 GIPC2 GIPC3 GOLGA2 HSF2BP KANK2 LNX1 M1AP MPDZ PLEKHA1 PTPN13 SNTG1 TEPSIN TRIM23	36 interacting genes: ACTN1 ADRB1 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SH3BP4 SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408
Entrez ID		59339	10755
HPRD ID			05462
Ensembl ID		ENSG00000169499	ENSG00000123159
Uniprot IDs		A0A087WZ32 A8K727 Q9HB19	A0A024R7I0 A0A024R7I1 A8K2I7 O14908
PDB IDs
Enriched GO Terms of Interacting Partners?
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