CSTB and RAD21

Data Source:
BioGRID (two hybrid)

		CSTB	RAD21
Description		cystatin B	RAD21 cohesin complex component
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Chromosome, Centromeric Region Synaptonemal Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Nuclear Mitotic Cohesin Complex Nuclear Meiotic Cohesin Complex
	Molecular Function	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity	Chromatin Binding Protein Binding
	Biological Process	Adult Locomotory Behavior Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Negative Regulation Of Proteolysis	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Mitotic Sister Chromatid Cohesion Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		Neutrophil degranulation	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs		Cupric Chloride
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Menopause (age at onset) ( 29773799)
Interacting Genes		8 interacting genes: CST3 CTSB CTSD CTSH CTSL ECT2 RAD21 SPRY2	30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		1476	5885
HPRD ID		03091	05924
Ensembl ID		ENSG00000160213	ENSG00000164754
Uniprot IDs		P04080 Q76LA1	A0A024R9J0 O60216
PDB IDs		1STF 2OCT 4N6V	4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE
Enriched GO Terms of Interacting Partners?
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