RABGGTB and RAB7A

Data Source:
HPRD (in vitro)

		RABGGTB	RAB7A
Description		Rab geranylgeranyltransferase subunit beta	RAB7A, member RAS oncogene family
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Retromer Complex Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Small GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding
	Biological Process	Cellular Protein Modification Process Visual Perception Protein Phosphopantetheinylation Protein Prenylation Protein Geranylgeranylation Regulation Of Apoptotic Process Post-translational Protein Modification	Autophagosome Assembly Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Endosome To Plasma Membrane Protein Transport Multi-organism Intercellular Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation	MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs		N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate	Guanosine-5'-Diphosphate
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)	Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		20 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A RABGGTA SH3GLB1 TAFA1 TMEM25 WDR4	27 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 SLC2A4 SNX3 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41
Entrez ID		5876	7879
HPRD ID		01532	03805
Ensembl ID		ENSG00000137955	ENSG00000075785
Uniprot IDs		A8KAJ2 P53611 Q6IB63	A0A158RFU6 P51149
PDB IDs		6J6X 6J74 6J7F 6J7X 6O60	1T91 1YHN 3LAW 6IYB 6WCW
Enriched GO Terms of Interacting Partners?
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