RABGGTB and IGFBP6

Data Source:
BioGRID (two hybrid)

		RABGGTB	IGFBP6
Description		Rab geranylgeranyltransferase subunit beta	insulin like growth factor binding protein 6
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex
	Molecular Function	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Small GTPase Binding	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding
	Biological Process	Cellular Protein Modification Process Visual Perception Protein Phosphopantetheinylation Protein Prenylation Protein Geranylgeranylation Regulation Of Apoptotic Process Post-translational Protein Modification	Activation Of MAPK Activity Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)
Interacting Genes		20 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A RABGGTA SH3GLB1 TAFA1 TMEM25 WDR4	37 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 EFEMP1 EFEMP2 ENKD1 EPDR1 GAS8 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Entrez ID		5876	3489
HPRD ID		01532	00902
Ensembl ID		ENSG00000137955	ENSG00000167779
Uniprot IDs		A8KAJ2 P53611 Q6IB63	P24592
PDB IDs		6J6X 6J74 6J7F 6J7X 6O60	1RMJ
Enriched GO Terms of Interacting Partners?
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