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RAB7A
Description
RAB7A, member RAS oncogene family
Image
GO Annotations
Cellular Component
Autophagosome Membrane
Lysosome
Lysosomal Membrane
Late Endosome
Lipid Droplet
Cytosol
Plasma Membrane
Endosome Membrane
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Retromer Complex
Late Endosome Membrane
Extrinsic Component Of Lysosome Membrane
Melanosome Membrane
Phagocytic Vesicle
Extracellular Exosome
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Retromer Complex Binding
Biological Process
Autophagosome Assembly
Protein Targeting To Lysosome
Endocytosis
Epidermal Growth Factor Catabolic Process
Endosome To Lysosome Transport
Protein Transport
Lipid Catabolic Process
Viral Release From Host Cell
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Protein To Membrane Docking
Retrograde Transport, Endosome To Golgi
Neutrophil Degranulation
Early Endosome To Late Endosome Transport
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Viral Process
Lipophagy
Phagosome Maturation
Phagosome Acidification
Phagosome-lysosome Fusion
Endosome To Plasma Membrane Protein Transport
Multi-organism Intercellular Transport
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Exosomal Secretion
Negative Regulation Of Intralumenal Vesicle Formation
Pathways
MHC class II antigen presentation
Neutrophil degranulation
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Prevention of phagosomal-lysosomal fusion
Suppression of autophagy
Drugs
Guanosine-5'-Diphosphate
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Body fat mass (
28552196
)
Facial morphology traits (63 three-dimensional facial segments) (
29459680
)
Novel Interacting Genes
8 novel interacting genes:
COPG1
ENOPH1
FABP6
GP9
H1-10
RPN1
TMCC1
ZHX2
Interacting Genes
27 interacting genes:
CHM
KRTAP10-3
KRTAP10-9
PPP2R1A
PPP2R1B
PRKN
RAB13
RAB17
RAB22A
RAB4A
RAB4B
RAB6A
RABAC1
RABGGTB
RILP
RNF115
SLC2A4
SNX3
TP53
UCHL5
VPS11
VPS16
VPS18
VPS26A
VPS29
VPS39
VPS41
Entrez ID
7879
HPRD ID
03805
Ensembl ID
ENSG00000075785
Uniprot IDs
A0A158RFU6
P51149
PDB IDs
1T91
1YHN
3LAW
6IYB
6WCW
Enriched GO Terms of Interacting Partners
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Tagcloud
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