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RAB7A and PPP2R1B
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
RAB7A
PPP2R1B
Description
RAB7A, member RAS oncogene family
protein phosphatase 2 scaffold subunit Abeta
Image
No pdb structure
GO Annotations
Cellular Component
Autophagosome Membrane
Lysosome
Lysosomal Membrane
Late Endosome
Lipid Droplet
Cytosol
Plasma Membrane
Endosome Membrane
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Retromer Complex
Late Endosome Membrane
Extrinsic Component Of Lysosome Membrane
Melanosome Membrane
Phagocytic Vesicle
Extracellular Exosome
Protein Phosphatase Type 2A Complex
Cytoplasm
Protein Serine/threonine Phosphatase Complex
Membrane Raft
Extracellular Exosome
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Retromer Complex Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Regulator Activity
Biological Process
Autophagosome Assembly
Protein Targeting To Lysosome
Endocytosis
Epidermal Growth Factor Catabolic Process
Endosome To Lysosome Transport
Protein Transport
Lipid Catabolic Process
Viral Release From Host Cell
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Protein To Membrane Docking
Retrograde Transport, Endosome To Golgi
Neutrophil Degranulation
Early Endosome To Late Endosome Transport
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Viral Process
Lipophagy
Phagosome Maturation
Phagosome Acidification
Phagosome-lysosome Fusion
Endosome To Plasma Membrane Protein Transport
Multi-organism Intercellular Transport
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Exosomal Secretion
Negative Regulation Of Intralumenal Vesicle Formation
Protein Dephosphorylation
Regulation Of Phosphoprotein Phosphatase Activity
Apoptotic Process Involved In Morphogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
MHC class II antigen presentation
Neutrophil degranulation
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Prevention of phagosomal-lysosomal fusion
Suppression of autophagy
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Drugs
Guanosine-5'-Diphosphate
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Body fat mass (
28552196
)
Facial morphology traits (63 three-dimensional facial segments) (
29459680
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Asthma (
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Brain morphology (MOSTest) (
32665545
)
Fish- and plant-related diet (
32066663
)
HDL cholesterol levels (
32203549
)
Mean spheric corpuscular volume (
32888494
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Red blood cell count (
32888494
)
Interacting Genes
27 interacting genes:
CHM
KRTAP10-3
KRTAP10-9
PPP2R1A
PPP2R1B
PRKN
RAB13
RAB17
RAB22A
RAB4A
RAB4B
RAB6A
RABAC1
RABGGTB
RILP
RNF115
SLC2A4
SNX3
TP53
UCHL5
VPS11
VPS16
VPS18
VPS26A
VPS29
VPS39
VPS41
40 interacting genes:
AKAP9
ANXA5
BHLHE41
BSG
CDK1
CDK4
CEP43
CFTR
CLOCK
CRY1
CRY2
CSNK2B
DELEC1
EEF2
FBXW11
HDAC1
HSPD1
JAK2
MCM3
PARK7
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5C
PPP2R5D
PPP2R5E
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RALA
RELA
RORC
SET
SGO1
SGO2
STRN
STRN3
UNC5B
Entrez ID
7879
5519
HPRD ID
03805
04384
Ensembl ID
ENSG00000075785
ENSG00000137713
Uniprot IDs
A0A158RFU6
P51149
P30154
PDB IDs
1T91
1YHN
3LAW
6IYB
6WCW
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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