RAB1A and OCRL

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		RAB1A	OCRL
Description		RAB1A, member RAS oncogene family	OCRL inositol polyphosphate-5-phosphatase
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GO Annotations	Cellular Component	Golgi Membrane Early Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Endomembrane System Transport Vesicle Membrane Melanosome Extracellular Exosome	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosome Early Endosome Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Phagocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Cadherin Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity
	Biological Process	Autophagosome Assembly Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Endocytosis Autophagy Golgi Organization Vesicle-mediated Transport Cell Migration Virion Assembly Growth Hormone Secretion Melanosome Transport Interleukin-8 Production Substrate Adhesion-dependent Cell Spreading Defense Response To Bacterium Post-translational Protein Modification Vesicle Transport Along Microtubule COPII Vesicle Coating Cilium Assembly COPII-coated Vesicle Cargo Loading Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Regulation Of Small GTPase Mediated Signal Transduction Cilium Assembly Membrane Organization
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Rho GTPase cycle Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases			Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis Lowe syndrome; Oculocerebrorenal Dystrophy (OCRL)
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Triglyceride levels ( 32154731)
Interacting Genes		28 interacting genes: ADCK1 CAPNS1 CDKN1A CHML CREB1 CSNK1D FSCN1 GOLGA2 GOLGA5 GORASP2 HIVEP1 MAPRE3 MICAL1 MICALL1 OCRL PSMD7 RABAC1 RABEP1 RABGGTA RABGGTB RABIF RFK RUSC2 SLC16A8 SYT5 TBC1D17 USO1 ZNF593	14 interacting genes: CDC42 CLTC GOLGA5 GRB2 LHX3 PHETA1 PHETA2 RAB14 RAB1A RAB31 RAB5A RAB6A RAB8A RAC1
Entrez ID		5861	4952
HPRD ID		01538	02395
Ensembl ID		ENSG00000138069	ENSG00000122126
Uniprot IDs		B7Z8M7 P62820 Q5U0I6	A0A2X0TVZ9 Q01968 Q504W7
PDB IDs		2FOL 2WWX 3L0I 3SFV 3TKL 4FMB 4FMC 4FMD 4FME 4IRU 4JVS	2KIE 2QV2 3QBT 3QIS 4CMN
Enriched GO Terms of Interacting Partners?
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