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RAB1A and PSMD7
Data Source:
HPRD
(two hybrid)
RAB1A
PSMD7
Description
RAB1A, member RAS oncogene family
proteasome 26S subunit, non-ATPase 7
Image
GO Annotations
Cellular Component
Golgi Membrane
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Endomembrane System
Transport Vesicle Membrane
Melanosome
Extracellular Exosome
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Membrane
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
Cadherin Binding
Protein Binding
Metallopeptidase Activity
Protein Homodimerization Activity
Isopeptidase Activity
Biological Process
Autophagosome Assembly
Intracellular Protein Transport
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Endocytosis
Autophagy
Golgi Organization
Vesicle-mediated Transport
Cell Migration
Virion Assembly
Growth Hormone Secretion
Melanosome Transport
Interleukin-8 Production
Substrate Adhesion-dependent Cell Spreading
Defense Response To Bacterium
Post-translational Protein Modification
Vesicle Transport Along Microtubule
COPII Vesicle Coating
Cilium Assembly
COPII-coated Vesicle Cargo Loading
Establishment Of Endothelial Intestinal Barrier
Positive Regulation Of Glycoprotein Metabolic Process
Positive Regulation Of Ubiquitin Protein Ligase Activity
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Neutrophil Degranulation
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Golgi Cisternae Pericentriolar Stack Reorganization
Golgi Cisternae Pericentriolar Stack Reorganization
COPII-mediated vesicle transport
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
High light scatter reticulocyte percentage of red cells (
32888494
)
Reticulocyte count (
32888494
)
Triglyceride levels (
32154731
)
Alcohol consumption (
31358974
)
Alcohol consumption (drinks per week) (
30679032
)
Photic sneeze reflex (
27182965
)
Interacting Genes
28 interacting genes:
ADCK1
CAPNS1
CDKN1A
CHML
CREB1
CSNK1D
FSCN1
GOLGA2
GOLGA5
GORASP2
HIVEP1
MAPRE3
MICAL1
MICALL1
OCRL
PSMD7
RABAC1
RABEP1
RABGGTA
RABGGTB
RABIF
RFK
RUSC2
SLC16A8
SYT5
TBC1D17
USO1
ZNF593
14 interacting genes:
ATXN3
LINC01554
PSMC1
PSMD1
PSMD14
PSMD3
PSMD4
PSMD6
PTEN
RAB1A
SLC2A4
TRAF6
UBC
VIM
Entrez ID
5861
5713
HPRD ID
01538
01147
Ensembl ID
ENSG00000138069
ENSG00000103035
Uniprot IDs
B7Z8M7
P62820
Q5U0I6
P51665
PDB IDs
2FOL
2WWX
3L0I
3SFV
3TKL
4FMB
4FMC
4FMD
4FME
4IRU
4JVS
2O95
2O96
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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