SNX6 and BRMS1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		SNX6	BRMS1
Description		sorting nexin 6	BRMS1 transcriptional repressor and anoikis regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Tubular Endosome	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex
	Molecular Function	Protein Binding Dynactin Binding Phosphatidylinositol Binding Protein Homodimerization Activity	Protein Binding Histone Deacetylase Binding NF-kappaB Binding
	Biological Process	Intracellular Protein Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Macroautophagy Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Histamine Secretion By Mast Cell Cellular Response To Amyloid-beta	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Deacetylation Positive Regulation Of Anoikis
Pathways			HDACs deacetylate histones Potential therapeutics for SARS
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Celiac disease ( 23936387) Diastolic blood pressure ( 30224653) Normal facial asymmetry (angle of surface orientation score) ( 30631343)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		25 interacting genes: ACVR2B ACVRL1 BMPR1B BRCA1 BRMS1 CALM1 COIL CSNK2A2 DISC1 EGFR ESR1 INSR LEPR NDEL1 OPTN PDGFRA PIM1 SNX1 SNX2 SNX4 TEX11 TGFBR1 TGFBR2 TNIK TPT1	49 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SUDS3 TAF1 THRSP UBE2D1
Entrez ID		58533	25855
HPRD ID		12086	05879
Ensembl ID		ENSG00000129515	ENSG00000174744
Uniprot IDs		A0A0A0MRI2 Q9UNH7	G5E9I4 Q9HCU9
PDB IDs			2XUS 4AUV
Enriched GO Terms of Interacting Partners?
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