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SNX6 and TGFBR2
Data Source:
HPRD
(in vivo, in vitro)
SNX6
TGFBR2
Description
sorting nexin 6
transforming growth factor beta receptor 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endosome
Cytosol
Retromer Complex
Retromer, Tubulation Complex
Early Endosome Membrane
Tubular Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
External Side Of Plasma Membrane
Integral Component Of Membrane
Receptor Complex
Membrane Raft
Molecular Function
Protein Binding
Dynactin Binding
Phosphatidylinositol Binding
Protein Homodimerization Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type II
Protein Binding
ATP Binding
Glycosaminoglycan Binding
Activin-activated Receptor Activity
Mitogen-activated Protein Kinase Kinase Kinase Binding
Type I Transforming Growth Factor Beta Receptor Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Biological Process
Intracellular Protein Transport
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Regulation Of Macroautophagy
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Retrograde Transport, Endosome To Golgi
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Histamine Secretion By Mast Cell
Cellular Response To Amyloid-beta
Blood Vessel Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Response To Hypoxia
In Utero Embryonic Development
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Tolerance Induction To Self Antigen
Positive Regulation Of B Cell Tolerance Induction
Positive Regulation Of T Cell Tolerance Induction
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Outflow Tract Morphogenesis
Atrioventricular Valve Morphogenesis
Tricuspid Valve Morphogenesis
Cardiac Left Ventricle Morphogenesis
Endocardial Cushion Fusion
Growth Plate Cartilage Chondrocyte Growth
Protein Phosphorylation
Receptor-mediated Endocytosis
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
Notch Signaling Pathway
Smoothened Signaling Pathway
Gastrulation
Brain Development
Heart Development
Embryo Implantation
Aging
Response To Nutrient
Positive Regulation Of Cell Population Proliferation
Response To Mechanical Stimulus
Response To Glucose
Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Animal Organ Regeneration
Activation Of Protein Kinase Activity
Activin Receptor Signaling Pathway
Embryonic Hemopoiesis
Wound Healing
Regulation Of Cell Population Proliferation
Response To Drug
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Skeletal Muscle Tissue Regeneration
Response To Estrogen
Positive Regulation Of Angiogenesis
Response To Steroid Hormone
Digestive Tract Development
Positive Regulation Of Smooth Muscle Cell Proliferation
Embryonic Cranial Skeleton Morphogenesis
Positive Regulation Of NK T Cell Differentiation
Negative Regulation Of Cardiac Muscle Cell Proliferation
Pathway-restricted SMAD Protein Phosphorylation
Ventricular Septum Morphogenesis
Bronchus Morphogenesis
Trachea Formation
Mammary Gland Morphogenesis
Lung Lobe Morphogenesis
Secondary Palate Development
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cell Proliferation Involved In Endocardial Cushion Morphogenesis
Superior Endocardial Cushion Morphogenesis
Inferior Endocardial Cushion Morphogenesis
Lens Fiber Cell Apoptotic Process
MiRNA Transport
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
Drugs
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Fostamatinib
Diseases
Colorectal cancer
Loeys-Dietz syndrome (LDS)
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Atrial fibrillation (
29892015
)
Celiac disease (
23936387
)
Diastolic blood pressure (
30224653
)
Normal facial asymmetry (angle of surface orientation score) (
30631343
)
Breast cancer (
29059683
23535729
)
Cellular nuclear factor (erythroid-derived 2)-like 2 levels (
30767168
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
Migraine (
22683712
27322543
)
Migraine - clinic-based (
23793025
)
Night sleep phenotypes (
27126917
)
Postprandial triglyceride response (
32603185
)
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) (
25117820
)
Systolic blood pressure (
30224653
)
Tonometry (
17903302
)
Interacting Genes
25 interacting genes:
ACVR2B
ACVRL1
BMPR1B
BRCA1
BRMS1
CALM1
COIL
CSNK2A2
DISC1
EGFR
ESR1
INSR
LEPR
NDEL1
OPTN
PDGFRA
PIM1
SNX1
SNX2
SNX4
TEX11
TGFBR1
TGFBR2
TNIK
TPT1
50 interacting genes:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CCNB1
CCNB2
CD44
CDK1
CLU
CTNNB1
DAB2
DAXX
DYNLT4
EIF3I
ENG
FANCC
GOPC
KCNK18
MAP2K1
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
PPP2CB
PSMD14
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TDGF1
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TRMO
TSSK1B
ZFYVE9
ZNF510
Entrez ID
58533
7048
HPRD ID
12086
01823
Ensembl ID
ENSG00000129515
ENSG00000163513
Uniprot IDs
A0A0A0MRI2
Q9UNH7
A3QNQ0
D2JYI1
P37173
PDB IDs
1KTZ
1M9Z
1PLO
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5QIN
5TX4
5TY4
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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