CSNK2A2 and PPP1R1B

Data Source:
HPRD (in vitro)

		CSNK2A2	PPP1R1B
Description		casein kinase 2 alpha 2	protein phosphatase 1 regulatory inhibitor subunit 1B
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex PcG Protein Complex	Nucleus Cytoplasm Cytosol Neuronal Cell Body Dendritic Spine Neck Dendritic Spine Head Glutamatergic Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Kinase Inhibitor Activity Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity D1 Dopamine Receptor Binding D2 Dopamine Receptor Binding D3 Dopamine Receptor Binding D4 Dopamine Receptor Binding D5 Dopamine Receptor Binding
	Biological Process	Protein Folding Phosphatidylcholine Biosynthetic Process Apoptotic Process Cell Cycle Spermatogenesis Wnt Signaling Pathway Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebral Cortex Development Regulation Of Cell Cycle Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway	Response To Amphetamine Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Signal Transduction Memory Negative Regulation Of Female Receptivity Locomotory Behavior Visual Learning Negative Regulation Of Phosphoprotein Phosphatase Activity Response To Nicotine Intracellular Signal Transduction Response To Morphine Behavioral Response To Cocaine
Pathways		Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity	DARPP-32 events DARPP-32 events
Drugs		[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib
Diseases
GWAS		Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)	Asthma ( 31959851 31619474) Estimated glomerular filtration rate ( 31015462) Hematocrit ( 32888494) Hemoglobin ( 32888494) Refractive error ( 32231278) Ulcerative colitis ( 20228799)
Interacting Genes		102 interacting genes: ABCA1 ACACA ADH1A AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERCC6 ERH FGF1 FGF2 FKBP3 FOS GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PICK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP53 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3	9 interacting genes: CDK5 CSNK2A1 CSNK2A2 DLGAP4 KLHL6 PPP1CA PRKACA ROBO2 TFCP2
Entrez ID		1459	84152
HPRD ID		00279	05097
Ensembl ID		ENSG00000070770	ENSG00000131771
Uniprot IDs		P19784	A0A024R1R3 B3KVQ9 Q9UD71
PDB IDs		3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6L20 6QY8 6QY9 6TE2 6TEW 6TGU
Enriched GO Terms of Interacting Partners?
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