CSNK2A2 and KDM1A

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)

		CSNK2A2	KDM1A
Description		casein kinase 2 alpha 2	lysine demethylase 1A
Image
GO Annotations	Cellular Component	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex PcG Protein Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex DNA Repair Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Transcription Factor Binding P53 Binding Chromatin Binding Protein Binding Transcription Factor Binding Oxidoreductase Activity Enzyme Binding Nuclear Receptor Coactivator Activity Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-K9 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) Telomeric DNA Binding MRF Binding Flavin Adenine Dinucleotide Binding Androgen Receptor Binding Telomeric Repeat-containing RNA Binding Promoter-specific Chromatin Binding
	Biological Process	Protein Folding Phosphatidylcholine Biosynthetic Process Apoptotic Process Cell Cycle Spermatogenesis Wnt Signaling Pathway Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebral Cortex Development Regulation Of Cell Cycle Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Protein Demethylation Blood Coagulation Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Neuron Projection Development Cerebral Cortex Development Negative Regulation Of Protein Binding Histone H3-K9 Demethylation Positive Regulation Of Histone Ubiquitination Cellular Response To UV Histone H3-K4 Demethylation Positive Regulation Of Chromatin Binding Neuron Maturation Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Size Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Guanine Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Muscle Cell Development Response To Fungicide Cellular Response To CAMP Cellular Response To Gamma Radiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Protein Localization Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity	HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
Drugs		[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib
Diseases
GWAS		Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Gamma glutamyl transferase levels ( 29403010) Global electrical heterogeneity phenotypes ( 29622589) Pulse pressure ( 27841878) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		102 interacting genes: ABCA1 ACACA ADH1A AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERCC6 ERH FGF1 FGF2 FKBP3 FOS GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PICK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP53 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3	265 interacting genes: AKAP9 ANKEF1 ANKRD23 AP1G2 AR ARHGAP15 ARHGAP29 ASB10 ASB3 ASCC2 ATP5MF ATP6V1B1 BAHD1 BAIAP2 BATF BCAT1 BIRC2 BLZF1 BMP3 BRCA1 C18orf54 C4orf17 C8orf48 C8orf74 CAGE1 CARD10 CCDC121 CCDC14 CCDC172 CCDC33 CCDC74A CCDC74B CCDC90B CDC23 CDC5L CDCA4 CDCA5 CENPQ CEP162 CEP57 CEP70 CEP76 CFAP100 COIL CRBN CRLF3 CSNK2A1 CSNK2A2 CTBP1 DBF4B DNAAF4 DNAJA3 DNTTIP1 E2F1 ECI2 ELOF1 EXOC1 EXOC7 FAM161A FAM204A FAM9A FIGNL1 FYCO1 FYN GABPB2 GAS8 GATA3 GCC1 GDF9 GLYR1 GOLGA2 GOLGA6A GPATCH2L GSK3B GSTCD GTPBP2 H3-4 H3-5 H3C1 H3C14 HAUS1 HAUS3 HAUS6 HDAC1 HESX1 HOMER3 HOXA1 ID2 IFI35 IGFBP4 IK IKBIP IL16 IMMT INSM1 INTS2 ISL1 ITGB3BP ITSN2 JRK KANSL1 KASH5 KDM5B KIAA0408 KIFC3 KLC3 KLF3 KLHDC4 KRT15 KRT17 KRT19 KRT222 KRT31 KRT33B KRT35 KRT38 KRT39 KRT40 KRT6A KRT6B KRT7 L3MBTL3 LENG8 LINC02875 LOXL4 LZTS1 MALT1 MBD3 MBD4 MCPH1 MCRS1 METTL27 MLC1 MNS1 MTA3 MTF2 MTMR9 MTO1 MYC MYLIP NBPF15 NBPF26 NDUFA8 NDUFS1 NECAB2 NEFL NF2 NFE2L2 NMI NOSTRIN NR1H2 NR1H3 NR2C2 NR2E1 NRBF2 ODAD3 OFCC1 OIP5 OPA3 OTUB1 PBX4 PDCD5 PDE4DIP PEX7 PFDN5 PHC2 PHF19 PHF20L1 PHF21A PMF1 PNKP PPARD PPM1D PPP1R12A PRDM1 PRIM2 PSMC1 PSMC3 PTEN RASSF1 RASSF2 RASSF3 RASSF8 RCOR1 RCOR3 RIOK1 RNF10 RNF168 RPRD1A SAMD3 SEPTIN6 SERGEF SETDB1 SF3B2 SH3GLB2 SLU7 SMAD9 SMARCD1 SMN1 SNF8 SNX15 SOCS6 SPATA22 SPATA24 SPICE1 SPRY2 SPSB1 SPZ1 SRGAP3 SSX2IP STAT3 STX11 STX19 SUMO2 SUV39H1 TACC1 TADA3 TAL1 TDO2 TEDC2 TERF1 TEX35 TEX9 TFIP11 TLE5 TMEM266 TNFAIP1 TNNT2 TP53 TP53BP1 TP53BP2 TRAF4 TRIM39 TRIM54 TSACC TSC1 TTC23 TTC33 UBA3 UBASH3B UBE2I UCHL5 UNC119 UNKL USP28 USP7 VPS11 VPS37A VPS37B WASHC3 WDR83 ZBED1 ZBTB24 ZBTB39 ZCCHC17 ZFP28 ZNF280A ZNF333 ZNF436 ZNF451 ZNF480 ZNF581 ZNF641 ZNF71 ZNF829
Entrez ID		1459	23028
HPRD ID		00279	09800
Ensembl ID		ENSG00000070770	ENSG00000004487
Uniprot IDs		P19784	O60341
PDB IDs		3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6L20 6QY8 6QY9 6TE2 6TEW 6TGU	2COM 2DW4 2EJR 2H94 2HKO 2IW5 2L3D 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 2Z3Y 2Z5U 3ABT 3ABU 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1 4BAY 4CZZ 4KUM 4UV8 4UV9 4UVA 4UVB 4UVC 4UXN 4XBF 5AFW 5H6Q 5H6R 5IT3 5L3B 5L3C 5L3D 5L3E 5L3F 5L3G 5LBQ 5LGN 5LGT 5LGU 5LHG 5LHH 5LHI 5X60 5YJB 6E1F 6K3E 6KGK 6KGL 6KGM 6KGN 6KGO 6KGP 6KGQ 6KGR 6NQM 6NQU 6NR5 6S35 6TE1 6VYP 6W4K 7JJL 7JJM 7JK7
Enriched GO Terms of Interacting Partners?
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