PTPRR and RYK

Data Source:
BioGRID (two hybrid)

		PTPRR	RYK
Description		protein tyrosine phosphatase receptor type R	receptor like tyrosine kinase
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GO Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Integral Component Of Membrane Cell Junction Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	In Utero Embryonic Development Protein Dephosphorylation Negative Regulation Of Epithelial Cell Migration Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Homophilic Cell Adhesion	Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axonogenesis Axon Guidance Synapse Assembly Wnt Signaling Pathway Peptidyl-tyrosine Phosphorylation Neurogenesis Corpus Callosum Development Neuron Differentiation Neuron Projection Development Cell Proliferation In Midbrain Positive Regulation Of Kinase Activity Non-canonical Wnt Signaling Pathway Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of MAPK Cascade Skeletal System Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Commissural Neuron Axon Guidance Planar Cell Polarity Pathway Involved In Axon Guidance Midbrain Dopaminergic Neuron Differentiation Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Pathways			TCF dependent signaling in response to WNT PCP/CE pathway
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) HDL cholesterol levels ( 32203549) Influenza A (H1N1) infection ( 26379185) Intraocular pressure ( 29785010) Mild influenza (H1N1) infection ( 26379185) Monobrow ( 27182965) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Uterine fibroids ( 31649266)	Cadmium levels ( 26025379) Diastolic blood pressure ( 27841878 30578418) Height ( 31562340) Systolic blood pressure ( 28135244 27841878)
Interacting Genes		25 interacting genes: AATK EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 FGFR4 GABARAPL1 IGF1R INSR KDR LMTK2 MAPK1 MAPK3 MAPK7 MST1R NTRK1 PRKACA PTK7 RET ROR1 ROR2 RYK TEK	8 interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A
Entrez ID		5801	6259
HPRD ID		04169	02751
Ensembl ID		ENSG00000153233	ENSG00000163785
Uniprot IDs		Q15256 Q7Z2V8	P34925 Q59FQ5 Q8WTZ8
PDB IDs		2A8B	6TUA
Enriched GO Terms of Interacting Partners?
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