RYK and EPHB2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RYK	EPHB2
Description		receptor like tyrosine kinase	EPH receptor B2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Receptor Complex	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuron Projection Neuronal Cell Body Receptor Complex Postsynapse Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	Amyloid-beta Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axonogenesis Axon Guidance Synapse Assembly Wnt Signaling Pathway Peptidyl-tyrosine Phosphorylation Neurogenesis Corpus Callosum Development Neuron Differentiation Neuron Projection Development Cell Proliferation In Midbrain Positive Regulation Of Kinase Activity Non-canonical Wnt Signaling Pathway Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of MAPK Cascade Skeletal System Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Commissural Neuron Axon Guidance Planar Cell Polarity Pathway Involved In Axon Guidance Midbrain Dopaminergic Neuron Differentiation Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation	Angiogenesis Urogenital System Development Negative Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Or Memory Learning Positive Regulation Of Gene Expression Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Blood Coagulation Retinal Ganglion Cell Axon Guidance Positive Regulation Of Synaptic Plasticity Positive Regulation Of Kinase Activity Inner Ear Morphogenesis Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Inactivation Of MAPKK Activity Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Commissural Neuron Axon Guidance Postsynaptic Membrane Assembly Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Neuron Projection Retraction Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of NMDA Glutamate Receptor Activity Positive Regulation Of NMDA Glutamate Receptor Activity
Pathways		TCF dependent signaling in response to WNT PCP/CE pathway	EPH-Ephrin signaling EPH-Ephrin signaling L1CAM interactions EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Fostamatinib
Diseases
GWAS		Cadmium levels ( 26025379) Diastolic blood pressure ( 27841878 30578418) Height ( 31562340) Systolic blood pressure ( 28135244 27841878)	Blood protein levels ( 30072576 29875488 28240269) Refractive error ( 32231278) Triiodothyronine levels ( 30843173) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		8 interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A	39 interacting genes: ABL1 ABL2 ACP1 AFDN AQP1 ARHGEF6 CRK EFNA5 EFNB1 EFNB2 ERBB2 ERF FBXO7 FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MMP2 MMP9 MTMR14 NCK1 PICK1 PLCG1 PTK2 RASA1 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 TRIM54 VAV2 VEGFA YES1
Entrez ID		6259	2048
HPRD ID		02751	02997
Ensembl ID		ENSG00000163785	ENSG00000133216
Uniprot IDs		P34925 Q59FQ5 Q8WTZ8	B4DSE0 P29323 Q4LE53 Q6NVW1
PDB IDs		6TUA	1B4F 1F0M 2QBX 3ZFM
Enriched GO Terms of Interacting Partners?
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