PTPRR and TEK

Data Source:
BioGRID (two hybrid)

		PTPRR	TEK
Description		protein tyrosine phosphatase receptor type R	TEK receptor tyrosine kinase
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GO Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Integral Component Of Membrane Cell Junction Perinuclear Region Of Cytoplasm	Stress Fiber Extracellular Region Cytoplasm Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Centriolar Satellite Receptor Complex Membrane Raft
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Growth Factor Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	In Utero Embryonic Development Protein Dephosphorylation Negative Regulation Of Epithelial Cell Migration Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Homophilic Cell Adhesion	MAPK Cascade Angiogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Sprouting Angiogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Heart Development Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Positive Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Angiogenesis Protein Autophosphorylation Tie Signaling Pathway Negative Regulation Of Inflammatory Response Leukocyte Migration Response To CAMP Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Glomerulus Vasculature Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Actin Cytoskeleton Reorganization Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade
Drugs			Ampicillin Vandetanib N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE Regorafenib Ponatinib Fostamatinib Ripretinib
Diseases			Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) HDL cholesterol levels ( 32203549) Influenza A (H1N1) infection ( 26379185) Intraocular pressure ( 29785010) Mild influenza (H1N1) infection ( 26379185) Monobrow ( 27182965) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Uterine fibroids ( 31649266)	Adult asthma ( 27611488) Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 27611488) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821)
Interacting Genes		25 interacting genes: AATK EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 FGFR4 GABARAPL1 IGF1R INSR KDR LMTK2 MAPK1 MAPK3 MAPK7 MST1R NTRK1 PRKACA PTK7 RET ROR1 ROR2 RYK TEK	25 interacting genes: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP CAV1 DOK2 DOK4 DUSP18 GRB14 GRB2 GRB7 IKBKG ILKAP PIK3R1 PTPN11 PTPRB PTPRR SHC1 SOCS1 STAT5A STAT5B STYX TIE1 TNIP2
Entrez ID		5801	7010
HPRD ID		04169	02571
Ensembl ID		ENSG00000153233	ENSG00000120156
Uniprot IDs		Q15256 Q7Z2V8	Q02763 Q59HG2
PDB IDs		2A8B	1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V 4X3J 5MYA 5MYB 5UTK 6MWE
Enriched GO Terms of Interacting Partners?
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