PTPRR and IGF1R

Data Source:
BioGRID (two hybrid)

		PTPRR	IGF1R
Description		protein tyrosine phosphatase receptor type R	insulin like growth factor 1 receptor
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GO Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Integral Component Of Membrane Cell Junction Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Membrane Axon Alphav-beta3 Integrin-IGF-1-IGF1R Complex Intracellular Membrane-bounded Organelle Receptor Complex Protein Kinase Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor-activated Receptor Activity Insulin Receptor Binding Protein Binding Insulin-like Growth Factor Binding ATP Binding Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding Protein Transporter Activity
	Biological Process	In Utero Embryonic Development Protein Dephosphorylation Negative Regulation Of Epithelial Cell Migration Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Homophilic Cell Adhesion	Immune Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Positive Regulation Of Cell Migration Positive Regulation Of Kinase Activity Peptidyl-tyrosine Autophosphorylation Glucose Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MAPK Cascade Transcytosis Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Inactivation Of MAPKK Activity Positive Regulation Of Protein Kinase B Signaling Cellular Response To Glucose Stimulus Dendritic Spine Maintenance Amyloid-beta Clearance Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Amyloid-beta
Pathways			Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Extra-nuclear estrogen signaling
Drugs			Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Phosphoaminophosphonic Acid-Adenylate Ester ATL1101 XL228 rhIGFBP-3 Linsitinib Teprotumumab (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE Somatrem Insulin degludec Cixutumumab Brigatinib Mecasermin rinfabate
Diseases			Malignant pleural mesothelioma Synovial sarcoma
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) HDL cholesterol levels ( 32203549) Influenza A (H1N1) infection ( 26379185) Intraocular pressure ( 29785010) Mild influenza (H1N1) infection ( 26379185) Monobrow ( 27182965) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Uterine fibroids ( 31649266)	Adult body size ( 32376654) Arthritis (juvenile idiopathic) ( 22354554) Atrial fibrillation ( 30061737 29892015) Birth weight ( 31043758 27680694) Blood urea nitrogen levels ( 31152163 29403010) Creatinine levels ( 29124443 29403010) Dental caries (decayed and filled deciduous teeth) ( 31533690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometriosis ( 27506219) Estimated glomerular filtration rate ( 31152163 31015462 29124443 30604766) Fasting plasma glucose ( 25187374) Global electrical heterogeneity phenotypes ( 29622589) Glomerular filtration rate ( 29403010) Height ( 28552196 20881960 25429064 31562340) Hemoglobin ( 32888494) Hyperuricemia ( 29124443) Offspring birth weight ( 31043758) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) QRS duration ( 30012220) Red cell distribution width ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Serum uric acid levels ( 30993211 29124443 29403010) Smoking status (ever vs never smokers) ( 30643258) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Urate levels ( 31985003 31578528 23263486) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		25 interacting genes: AATK EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 FGFR4 GABARAPL1 IGF1R INSR KDR LMTK2 MAPK1 MAPK3 MAPK7 MST1R NTRK1 PRKACA PTK7 RET ROR1 ROR2 RYK TEK	95 interacting genes: AMY2A APP ARHGEF12 BAP1 CAV1 CBL CDK4 CDKN2B CRK CRKL CSK CYP17A1 DOK4 DOK5 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 EEA1 EHD1 ERBB2 ESR1 FFAR2 FGFR4 GIPC1 GNAI1 GNAI2 GRB10 GRB14 GRM1 HOXC6 IGF1 IGF2 IGFBP3 IL13RA2 ILKAP INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KDELR2 KL KLK5 KRT27 LYPD3 MAP3K5 MDM2 MTA3 NAT2 NEDD4 NF2 PCNA PIK3R1 PIK3R2 PIK3R3 PPM1A PRKCD PRKD1 PTPN1 PTPN11 PTPN12 PTPN6 PTPN7 PTPRR RACK1 RASA1 RELA RPL11 SH2B1 SHC1 SIRPA SOCS1 SOCS2 SOCS3 SRC STAT3 STYX THRSP TTYH2 UBC VAV3 VPS45 YWHAB YWHAE YWHAG YWHAZ
Entrez ID		5801	3480
HPRD ID		04169	00932
Ensembl ID		ENSG00000153233	ENSG00000140443
Uniprot IDs		Q15256 Q7Z2V8	C9J5X1 P08069
PDB IDs		2A8B	1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU 4D2R 4XSS 5FXQ 5FXR 5FXS 5HZN 5U8Q 5U8R 6JK8 6VWG 6VWH 6VWI 6VWJ
Enriched GO Terms of Interacting Partners?
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