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BARD1 and FEZ1
Data Source:
HPRD
(two hybrid)
BARD1
FEZ1
Description
BRCA1 associated RING domain 1
fasciculation and elongation protein zeta 1
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
Cytoplasm
Mitochondrion
Golgi Apparatus
Centrosome
Microtubule
Plasma Membrane
Axon
Dendrite
Growth Cone
Neuronal Cell Body
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Protein Kinase C Binding
Protein Binding
Gamma-tubulin Binding
Protein N-terminus Binding
Biological Process
DNA Double-strand Break Processing
Tissue Homeostasis
DNA Replication
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Protein Ubiquitination
Protein Deubiquitination
Negative Regulation Of MRNA 3'-end Processing
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Export From Nucleus
Protein K6-linked Ubiquitination
Regulation Of Signal Transduction By P53 Class Mediator
Cell Adhesion
Nervous System Development
Axon Guidance
Positive Regulation Of Neuron Projection Development
Hippocampus Development
Establishment Of Cell Polarity
Positive Regulation Of Neuron Differentiation
Establishment Of Mitochondrion Localization
Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion
Mitochondrion Morphogenesis
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Autophagosome Assembly
Pathways
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Drugs
Diseases
GWAS
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
22941191
21124317
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
Breast cancer (survival) (
25890600
)
Schizophrenia (
22688191
23894747
)
Interacting Genes
125 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AX
H2BC21
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RPS20
SELENBP1
SETDB1
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WDR61
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
57 interacting genes:
BARD1
BORA
BRD1
C8orf33
CCL7
CEP126
CIB1
CLASP2
COL9A2
CSTF2
DIS3L2
DISC1
DNAAF5
DRAP1
FEZ2
GEMIN7
GTF2F1
HAP1
HTATSF1
HTT
IMMT
LRIF1
MEST
NBR1
NDUFB9
NEK1
OLFML3
P4HB
PAM16
PDCD7
PPP4R3B
PRKCZ
PTH
PTN
PTPRS
RAB3GAP1
RAB3GAP2
RAI14
RIF1
SAP30L
SCOC
SERPINH1
SMARCD1
SMC3
STAR
TAC3
TAF1D
TAF9
TBC1D25
TEDC2
TLK2
TOMM20
TTR
TXNDC9
UBE4B
WWC1
ZNF251
Entrez ID
580
9638
HPRD ID
03354
09212
Ensembl ID
ENSG00000138376
ENSG00000149557
Uniprot IDs
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
Q99689
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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