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PTH and MEP1A
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vitro)
PTH
MEP1A
Description
parathyroid hormone
meprin A subunit alpha
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Space
Integral Component Of Plasma Membrane
Meprin A Complex
Extracellular Exosome
Molecular Function
Hormone Activity
Protein Binding
Parathyroid Hormone Receptor Binding
Type 1 Parathyroid Hormone Receptor Binding
Protein N-terminus Binding
Receptor Ligand Activity
Peptide Hormone Receptor Binding
Metalloendopeptidase Activity
Protein Binding
Zinc Ion Binding
Biological Process
Skeletal System Development
Cellular Calcium Ion Homeostasis
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Rho Protein Signal Transduction
Cell-cell Signaling
Hormone-mediated Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction
Response To Lead Ion
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Magnesium Ion Homeostasis
Positive Regulation Of Bone Mineralization
Negative Regulation Of Chondrocyte Differentiation
Response To Vitamin D
Cellular Macromolecule Biosynthetic Process
Response To Drug
Bone Resorption
Response To Ethanol
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
CAMP Metabolic Process
Positive Regulation Of Glucose Import
Response To Cadmium Ion
Homeostasis Of Number Of Cells Within A Tissue
Negative Regulation Of Calcium Ion Transport
Phosphate Ion Homeostasis
Positive Regulation Of Inositol Phosphate Biosynthetic Process
Response To Parathyroid Hormone
Response To Fibroblast Growth Factor
Positive Regulation Of Cell Proliferation In Bone Marrow
Negative Regulation Of Apoptotic Process In Bone Marrow Cell
Positive Regulation Of Osteoclast Proliferation
Negative Regulation Of Bone Mineralization Involved In Bone Maturation
Proteolysis
Pathways
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Drugs
D-norleucine
ABX-PTH
Diseases
GWAS
Bone mineral density (
19874204
)
Childhood ear infection (
27182965
)
Menarche (age at onset) (
25231870
)
Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel (
28935272
)
Interacting Genes
6 interacting genes:
ASPH
BAG6
FEZ1
MEP1A
PTH1R
PTH2R
18 interacting genes:
AGT
CCK
FN1
GCG
GNRH1
GRP
KNG1
LAMA1
LAMA5
MEP1B
NPY
NTS
PLG
POMC
PTH
SCT
TAC1
VIP
Entrez ID
5741
4224
HPRD ID
01345
02666
Ensembl ID
ENSG00000152266
ENSG00000112818
Uniprot IDs
P01270
B7ZL91
Q16819
PDB IDs
1BWX
1ET1
1ET2
1FVY
1HPH
1HPY
1HTH
1ZWA
1ZWB
1ZWD
1ZWE
1ZWF
1ZWG
2L1X
3C4M
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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