CLK4 and KPNA1

Data Source:
BioGRID (two hybrid)

		CLK4	KPNA1
Description		CDC like kinase 4	karyopherin subunit alpha 1
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GO Annotations	Cellular Component	Nucleus	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Host Cell Glutamatergic Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Modulation By Virus Of Host Cellular Process Regulation Of Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Intracellular Transport Of Virus Postsynapse To Nucleus Signaling Pathway
Pathways			ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production
Drugs		Fostamatinib
Diseases
GWAS		Urate levels in obese individuals ( 25811787)	Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		12 interacting genes: CLASRP HSPB2 KPNA1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 RNF181 SRPK1 SRRM4 UBL5	45 interacting genes: ANP32A ANP32B ARNT BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMNB1 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP50 NUP54 NUP62 ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1
Entrez ID		57396	3836
HPRD ID		12140	02819
Ensembl ID		ENSG00000113240	ENSG00000114030
Uniprot IDs		Q9HAZ1	B3KXZ2 P52294
PDB IDs		6FYV	2JDQ 3TJ3 4B18 6WX9
Enriched GO Terms of Interacting Partners?
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