CLK4 and RNF181

		CLK4	RNF181
Description		CDC like kinase 4	ring finger protein 181
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation	Protein Ubiquitination Protein Autoubiquitination
Pathways			E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Fostamatinib
Diseases
GWAS		Urate levels in obese individuals ( 25811787)	Prostate cancer ( 21743467)
Interacting Genes		12 interacting genes: CLASRP HSPB2 KPNA1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 RNF181 SRPK1 SRRM4 UBL5	22 interacting genes: BCL10 BIRC2 BTG1 CARD11 CLK4 MRPS6 NPY5R PEG10 RBCK1 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U VPS11 ZMYND10
Entrez ID		57396	51255
HPRD ID		12140	14236
Ensembl ID		ENSG00000113240	ENSG00000168894
Uniprot IDs		Q9HAZ1	Q9P0P0
PDB IDs		6FYV
Enriched GO Terms of Interacting Partners?
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